node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | FGF14 | ENSP00000275493 | ENSP00000365301 | epidermal growth factor receptor | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.885 |
EGFR | FLT1 | ENSP00000275493 | ENSP00000282397 | epidermal growth factor receptor | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.539 |
EGFR | PDGFRA | ENSP00000275493 | ENSP00000257290 | epidermal growth factor receptor | platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] | 0.717 |
EGFR | PDGFRB | ENSP00000275493 | ENSP00000261799 | epidermal growth factor receptor | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.820 |
FGF14 | EGFR | ENSP00000365301 | ENSP00000275493 | fibroblast growth factor 14; Probably involved in nervous system development and function | epidermal growth factor receptor | 0.885 |
FGF14 | FGFR1 | ENSP00000365301 | ENSP00000393312 | fibroblast growth factor 14; Probably involved in nervous system development and function | fibroblast growth factor receptor 1 | 0.879 |
FGF14 | FGFR2 | ENSP00000365301 | ENSP00000410294 | fibroblast growth factor 14; Probably involved in nervous system development and function | fibroblast growth factor receptor 2 | 0.881 |
FGF14 | FGFR3 | ENSP00000365301 | ENSP00000339824 | fibroblast growth factor 14; Probably involved in nervous system development and function | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.888 |
FGF14 | FGFR4 | ENSP00000365301 | ENSP00000292408 | fibroblast growth factor 14; Probably involved in nervous system development and function | fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of [...] | 0.900 |
FGF14 | FLT1 | ENSP00000365301 | ENSP00000282397 | fibroblast growth factor 14; Probably involved in nervous system development and function | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.842 |
FGF14 | KIT | ENSP00000365301 | ENSP00000288135 | fibroblast growth factor 14; Probably involved in nervous system development and function | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | 0.837 |
FGF14 | PDGFRA | ENSP00000365301 | ENSP00000257290 | fibroblast growth factor 14; Probably involved in nervous system development and function | platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] | 0.839 |
FGF14 | PDGFRB | ENSP00000365301 | ENSP00000261799 | fibroblast growth factor 14; Probably involved in nervous system development and function | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.838 |
FGF14 | TEK | ENSP00000365301 | ENSP00000369375 | fibroblast growth factor 14; Probably involved in nervous system development and function | TEK tyrosine kinase, endothelial; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inh [...] | 0.837 |
FGFR1 | FGF14 | ENSP00000393312 | ENSP00000365301 | fibroblast growth factor receptor 1 | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.879 |
FGFR2 | FGF14 | ENSP00000410294 | ENSP00000365301 | fibroblast growth factor receptor 2 | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.881 |
FGFR2 | FGFR3 | ENSP00000410294 | ENSP00000339824 | fibroblast growth factor receptor 2 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.600 |
FGFR3 | FGF14 | ENSP00000339824 | ENSP00000365301 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.888 |
FGFR3 | FGFR2 | ENSP00000339824 | ENSP00000410294 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | fibroblast growth factor receptor 2 | 0.600 |
FGFR4 | FGF14 | ENSP00000292408 | ENSP00000365301 | fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of [...] | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.900 |