NFKBIL1 protein (Homo sapiens) - STRING network view

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NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (381 aa)

Predicted Functional Partners:

RLTPR

0.750

WDR16

0.624

CACTIN

0.589

CXCL10

0.575

CCDC130

0.538

RBM42

0.538

NFKBID

0.507

ACN9

0.500

AIF1

0.487

PPP1R3B

0.452

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACN9	NFKBIL1	ENSP00000414066	ENSP00000365318	ACN9 homolog (S. cerevisiae)	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.500
ACN9	PPP1R3B	ENSP00000414066	ENSP00000308318	ACN9 homolog (S. cerevisiae)	protein phosphatase 1, regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated g [...]	0.499
ACN9	WDR16	ENSP00000414066	ENSP00000339449	ACN9 homolog (S. cerevisiae)	WD repeat domain 16; May play an essential role in the growth or survival of hepatocellular carcinoma (HCC)	0.692
AIF1	NFKBIL1	ENSP00000365227	ENSP00000365318	allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.487
CACTIN	NFKBIL1	ENSP00000248420	ENSP00000365318	cactin, spliceosome C complex subunit; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.589
CCDC130	NFKBIL1	ENSP00000221554	ENSP00000365318	coiled-coil domain containing 130	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.538
CCDC130	RBM42	ENSP00000221554	ENSP00000262633	coiled-coil domain containing 130	RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity)	0.649
CXCL10	NFKBIL1	ENSP00000305651	ENSP00000365318	chemokine (C-X-C motif) ligand 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.575
NFKBID	NFKBIL1	ENSP00000380109	ENSP00000365318	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity)	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.507
NFKBIL1	ACN9	ENSP00000365318	ENSP00000414066	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	ACN9 homolog (S. cerevisiae)	0.500
NFKBIL1	AIF1	ENSP00000365318	ENSP00000365227	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation	0.487
NFKBIL1	CACTIN	ENSP00000365318	ENSP00000248420	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	cactin, spliceosome C complex subunit; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing	0.589
NFKBIL1	CCDC130	ENSP00000365318	ENSP00000221554	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	coiled-coil domain containing 130	0.538
NFKBIL1	CXCL10	ENSP00000365318	ENSP00000305651	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	chemokine (C-X-C motif) ligand 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	0.575
NFKBIL1	NFKBID	ENSP00000365318	ENSP00000380109	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity)	0.507
NFKBIL1	PPP1R3B	ENSP00000365318	ENSP00000308318	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	protein phosphatase 1, regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated g [...]	0.452
NFKBIL1	RBM42	ENSP00000365318	ENSP00000262633	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity)	0.538
NFKBIL1	RLTPR	ENSP00000365318	ENSP00000334958	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.750
NFKBIL1	WDR16	ENSP00000365318	ENSP00000339449	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	WD repeat domain 16; May play an essential role in the growth or survival of hepatocellular carcinoma (HCC)	0.624
PPP1R3B	ACN9	ENSP00000308318	ENSP00000414066	protein phosphatase 1, regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated g [...]	ACN9 homolog (S. cerevisiae)	0.499

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