| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | CD8A | ENSP00000011653 | ENSP00000283635 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.997 |
| CD4 | CTLA4 | ENSP00000011653 | ENSP00000303939 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | cytotoxic T-lymphocyte-associated protein 4 | 0.820 |
| CD4 | DDX41 | ENSP00000011653 | ENSP00000422753 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | 0.722 |
| CD4 | FOXP3 | ENSP00000011653 | ENSP00000365380 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.981 |
| CD4 | GATA3 | ENSP00000011653 | ENSP00000368632 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.913 |
| CD4 | IL2 | ENSP00000011653 | ENSP00000226730 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.878 |
| CD4 | STAT5A | ENSP00000011653 | ENSP00000341208 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | 0.476 |
| CD4 | TGFB1 | ENSP00000011653 | ENSP00000221930 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.708 |
| CD4 | TNF | ENSP00000011653 | ENSP00000398698 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | tumor necrosis factor | 0.736 |
| CD8A | CD4 | ENSP00000283635 | ENSP00000011653 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.997 |
| CD8A | CTLA4 | ENSP00000283635 | ENSP00000303939 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | cytotoxic T-lymphocyte-associated protein 4 | 0.871 |
| CD8A | DDX41 | ENSP00000283635 | ENSP00000422753 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | 0.909 |
| CD8A | FOXP3 | ENSP00000283635 | ENSP00000365380 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.981 |
| CD8A | GATA3 | ENSP00000283635 | ENSP00000368632 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.720 |
| CD8A | IL2 | ENSP00000283635 | ENSP00000226730 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.991 |
| CD8A | NFATC2 | ENSP00000283635 | ENSP00000379330 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.509 |
| CD8A | STAT5A | ENSP00000283635 | ENSP00000341208 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | 0.937 |
| CD8A | TGFB1 | ENSP00000283635 | ENSP00000221930 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.725 |
| CD8A | TNF | ENSP00000283635 | ENSP00000398698 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | tumor necrosis factor | 0.892 |
| CTLA4 | CD4 | ENSP00000303939 | ENSP00000011653 | cytotoxic T-lymphocyte-associated protein 4 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.820 |
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