PDSS1 protein (Homo sapiens) - STRING network view

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PDSS1

prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 (415 aa)

Predicted Functional Partners:

COQ2

0.990

FDPS

0.943

GGPS1

0.941

PDSS2

0.936

DHDDS

0.933

FNTB

0.919

FDFT1

0.914

COQ9

0.912

ENSG00000254673

0.907

ADCK3

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCK3	COQ2	ENSP00000355739	ENSP00000310873	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	0.891
ADCK3	COQ9	ENSP00000355739	ENSP00000262507	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	0.984
ADCK3	FDPS	ENSP00000355739	ENSP00000349078	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate	0.417
ADCK3	PDSS1	ENSP00000355739	ENSP00000365388	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.900
ADCK3	PDSS2	ENSP00000355739	ENSP00000358033	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.899
COQ2	ADCK3	ENSP00000310873	ENSP00000355739	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	0.891
COQ2	COQ9	ENSP00000310873	ENSP00000262507	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	0.912
COQ2	FDFT1	ENSP00000310873	ENSP00000220584	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	farnesyl-diphosphate farnesyltransferase 1	0.457
COQ2	FDPS	ENSP00000310873	ENSP00000349078	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate	0.577
COQ2	GGPS1	ENSP00000310873	ENSP00000282841	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins	0.439
COQ2	PDSS1	ENSP00000310873	ENSP00000365388	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.990
COQ2	PDSS2	ENSP00000310873	ENSP00000358033	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.991
COQ9	ADCK3	ENSP00000262507	ENSP00000355739	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain	0.984
COQ9	COQ2	ENSP00000262507	ENSP00000310873	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB	0.912
COQ9	PDSS1	ENSP00000262507	ENSP00000365388	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.912
COQ9	PDSS2	ENSP00000262507	ENSP00000358033	coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity)	prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.909
DHDDS	ENSG00000254673	ENSP00000353104	ENSP00000435061	dehydrodolichyl diphosphate synthase	Uncharacterized protein	0.900
DHDDS	FDFT1	ENSP00000353104	ENSP00000220584	dehydrodolichyl diphosphate synthase	farnesyl-diphosphate farnesyltransferase 1	0.804
DHDDS	FDPS	ENSP00000353104	ENSP00000349078	dehydrodolichyl diphosphate synthase	farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate	0.956
DHDDS	FNTB	ENSP00000353104	ENSP00000246166	dehydrodolichyl diphosphate synthase	farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding	0.900

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