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STRINGSTRING
HADHB HADHB ACADM ACADM PCCB PCCB HLCS HLCS ACSS2 ACSS2 ACAA2 ACAA2 PCCA PCCA ACAA1 ACAA1 MCCC2 MCCC2 ALDH6A1 ALDH6A1 MCEE MCEE
"PCCA" - propionyl CoA carboxylase, alpha polypeptide in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCCApropionyl CoA carboxylase, alpha polypeptide (728 aa)    
Predicted Functional Partners:
PCCB
propionyl CoA carboxylase, beta polypeptide (559 aa)
score_image score_image   score_image score_image score_image score_image   0.999
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (726 aa)
score_image         score_image score_image   0.989
MCEE
methylmalonyl CoA epimerase (176 aa)
          score_image score_image   0.965
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta) (563 aa)
score_image score_image   score_image score_image   score_image   0.959
ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 (425 aa)
score_image     score_image   score_image score_image   0.928
ALDH6A1
aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (535 aa)
      score_image   score_image score_image   0.925
ACAA2
acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
      score_image   score_image score_image   0.922
HADHB
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
      score_image   score_image score_image   0.921
ACAA1
acetyl-CoA acyltransferase 1 (424 aa)
      score_image   score_image score_image   0.920
ACSS2
acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation (714 aa)
          score_image score_image   0.913
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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