| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG7 | BECN1 | ENSP00000346437 | ENSP00000355231 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.972 |
| ATG7 | ENSG00000250232 | ENSP00000346437 | ENSP00000365536 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | 0.561 |
| ATG7 | NBR1 | ENSP00000346437 | ENSP00000343479 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets | 0.788 |
| ATG7 | PIKFYVE | ENSP00000346437 | ENSP00000264380 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.519 |
| BECN1 | ATG7 | ENSP00000355231 | ENSP00000346437 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.972 |
| BECN1 | ENSG00000250232 | ENSP00000355231 | ENSP00000365536 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | 0.604 |
| BECN1 | NBR1 | ENSP00000355231 | ENSP00000343479 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets | 0.799 |
| BECN1 | PIKFYVE | ENSP00000355231 | ENSP00000264380 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.509 |
| ENSG00000250232 | ATG7 | ENSP00000365536 | ENSP00000346437 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.561 |
| ENSG00000250232 | BECN1 | ENSP00000365536 | ENSP00000355231 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.604 |
| ENSG00000250232 | ENSG00000268361 | ENSP00000365536 | ENSP00000472698 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | Uncharacterized protein | 0.598 |
| ENSG00000250232 | NBR1 | ENSP00000365536 | ENSP00000343479 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets | 0.547 |
| ENSG00000250232 | PARP1 | ENSP00000365536 | ENSP00000355759 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | 0.656 |
| ENSG00000250232 | PARP2 | ENSP00000365536 | ENSP00000250416 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks | 0.656 |
| ENSG00000250232 | PARP3 | ENSP00000365536 | ENSP00000381740 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | poly (ADP-ribose) polymerase family, member 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May b [...] | 0.656 |
| ENSG00000250232 | PARP4 | ENSP00000365536 | ENSP00000371419 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | poly (ADP-ribose) polymerase family, member 4 | 0.656 |
| ENSG00000250232 | PIKFYVE | ENSP00000365536 | ENSP00000264380 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.583 |
| ENSG00000250232 | XRCC1 | ENSP00000365536 | ENSP00000262887 | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | X-ray repair complementing defective repair in Chinese hamster cells 1; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents | 0.598 |
| ENSG00000268361 | ENSG00000250232 | ENSP00000472698 | ENSP00000365536 | Uncharacterized protein | Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | 0.598 |
| ENSG00000268361 | PARP1 | ENSP00000472698 | ENSP00000355759 | Uncharacterized protein | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | 0.848 |
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