| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHMP4A | TM9SF2 | ENSP00000324205 | ENSP00000365567 | charged multivesicular body protein 4A; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.553 |
| CHMP4A | UBC | ENSP00000324205 | ENSP00000344818 | charged multivesicular body protein 4A; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | ubiquitin C | 0.926 |
| COPS6 | PLCL1 | ENSP00000304102 | ENSP00000402861 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | phospholipase C-like 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C | 0.513 |
| COPS6 | TM9SF2 | ENSP00000304102 | ENSP00000365567 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.625 |
| COPS6 | UBC | ENSP00000304102 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | ubiquitin C | 0.973 |
| FXYD3 | TM9SF2 | ENSP00000389770 | ENSP00000365567 | FXYD domain containing ion transport regulator 3; Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.567 |
| MMGT1 | TM9SF2 | ENSP00000306220 | ENSP00000365567 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.644 |
| MMGT1 | UBC | ENSP00000306220 | ENSP00000344818 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) | ubiquitin C | 0.632 |
| PLCL1 | COPS6 | ENSP00000402861 | ENSP00000304102 | phospholipase C-like 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.513 |
| PLCL1 | TM9SF2 | ENSP00000402861 | ENSP00000365567 | phospholipase C-like 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.524 |
| PLCL1 | UBC | ENSP00000402861 | ENSP00000344818 | phospholipase C-like 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C | ubiquitin C | 0.497 |
| RAB9A | TM9SF2 | ENSP00000420127 | ENSP00000365567 | RAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.916 |
| RAB9A | UBC | ENSP00000420127 | ENSP00000344818 | RAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network | ubiquitin C | 0.798 |
| RPN2 | TM9SF2 | ENSP00000237530 | ENSP00000365567 | ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.671 |
| RPN2 | UBC | ENSP00000237530 | ENSP00000344818 | ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | ubiquitin C | 0.980 |
| SLC25A3 | TM9SF2 | ENSP00000228318 | ENSP00000365567 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.644 |
| SLC25A3 | UBC | ENSP00000228318 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | ubiquitin C | 0.976 |
| SRSF7 | TM9SF2 | ENSP00000325905 | ENSP00000365567 | serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10 | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | 0.644 |
| SRSF7 | UBC | ENSP00000325905 | ENSP00000344818 | serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10 | ubiquitin C | 0.924 |
| TM9SF2 | CHMP4A | ENSP00000365567 | ENSP00000324205 | transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter | charged multivesicular body protein 4A; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.553 |
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