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DDX17 DDX17 DDX5 DDX5 SNAI1 SNAI1 DHX16 DHX16 CDC5L CDC5L SLU7 SLU7 PRPF19 PRPF19 CWC25 CWC25 CDC40 CDC40 HELQ HELQ TFIP11 TFIP11
"DHX16" - DEAH in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
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protein homology
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[Homology]
Score
DHX16DEAH (Asp-Glu-Ala-His) box polypeptide 16 (1041 aa)    
Predicted Functional Partners:
TFIP11
tuftelin interacting protein 11; May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing (By similarity) (837 aa)
        score_image   score_image   0.734
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] (504 aa)
      score_image score_image   score_image   0.717
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17; RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation (731 aa)
      score_image score_image   score_image   0.717
CDC40
cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing (579 aa)
      score_image score_image   score_image   0.712
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation a [...] (614 aa)
      score_image score_image   score_image   0.703
HELQ
helicase, POLQ-like; DNA-dependent ATPase and 5’ to 3’ DNA helicase (1101 aa)
        score_image   score_image   0.690
CDC5L
CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa)
      score_image score_image   score_image   0.670
SLU7
SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (586 aa)
      score_image score_image   score_image   0.666
SNAI1
snail homolog 1 (Drosophila); Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CD [...] (264 aa)
            score_image   0.658
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae) (425 aa)
        score_image   score_image   0.637
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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