OTUD1 protein (Homo sapiens) - STRING network view

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OTUD1

OTU domain containing 1 (481 aa)

Predicted Functional Partners:

UBC

0.819

FLNC

0.750

RAD23A

0.740

FLNB

0.740

RAD23B

0.740

SCT

0.740

ZNF451

0.640

USP11

0.593

C4BPB

0.573

RIPK1

0.545

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4BPB	OTUD1	ENSP00000243611	ENSP00000365678	complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S	OTU domain containing 1	0.573
FLNB	FLNC	ENSP00000420213	ENSP00000327145	filamin B, beta	filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	0.513
FLNB	OTUD1	ENSP00000420213	ENSP00000365678	filamin B, beta	OTU domain containing 1	0.740
FLNB	UBC	ENSP00000420213	ENSP00000344818	filamin B, beta	ubiquitin C	0.951
FLNC	FLNB	ENSP00000327145	ENSP00000420213	filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	filamin B, beta	0.513
FLNC	OTUD1	ENSP00000327145	ENSP00000365678	filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	OTU domain containing 1	0.750
FLNC	UBC	ENSP00000327145	ENSP00000344818	filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	ubiquitin C	0.918
OTUD1	C4BPB	ENSP00000365678	ENSP00000243611	OTU domain containing 1	complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S	0.573
OTUD1	FLNB	ENSP00000365678	ENSP00000420213	OTU domain containing 1	filamin B, beta	0.740
OTUD1	FLNC	ENSP00000365678	ENSP00000327145	OTU domain containing 1	filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	0.750
OTUD1	RAD23A	ENSP00000365678	ENSP00000467024	OTU domain containing 1	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	0.740
OTUD1	RAD23B	ENSP00000365678	ENSP00000350708	OTU domain containing 1	RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome	0.740
OTUD1	RIPK1	ENSP00000365678	ENSP00000259808	OTU domain containing 1	receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...]	0.545
OTUD1	SCT	ENSP00000365678	ENSP00000176195	OTU domain containing 1	secretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach	0.740
OTUD1	UBC	ENSP00000365678	ENSP00000344818	OTU domain containing 1	ubiquitin C	0.819
OTUD1	USP11	ENSP00000365678	ENSP00000218348	OTU domain containing 1	ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks	0.593
OTUD1	ZNF451	ENSP00000365678	ENSP00000359740	OTU domain containing 1	zinc finger protein 451; May be involved in transcriptional regulation. Coactivator for steroid receptors	0.640
RAD23A	OTUD1	ENSP00000467024	ENSP00000365678	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	OTU domain containing 1	0.740
RAD23A	RAD23B	ENSP00000467024	ENSP00000350708	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome	0.818
RAD23A	UBC	ENSP00000467024	ENSP00000344818	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	ubiquitin C	0.999

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