| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C10orf10 | LEP | ENSP00000298295 | ENSP00000312652 | chromosome 10 open reading frame 10 | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | 0.817 |
| C10orf10 | SLC15A1 | ENSP00000298295 | ENSP00000365686 | chromosome 10 open reading frame 10 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.827 |
| CDX1 | SLC15A1 | ENSP00000231656 | ENSP00000365686 | caudal type homeobox 1; Could play a role in the terminal differentiation of the intestine | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.874 |
| CDX2 | SLC15A1 | ENSP00000370408 | ENSP00000365686 | caudal type homeobox 2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.919 |
| IFNG | SLC15A1 | ENSP00000229135 | ENSP00000365686 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.780 |
| LEP | C10orf10 | ENSP00000312652 | ENSP00000298295 | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | chromosome 10 open reading frame 10 | 0.817 |
| LEP | SLC15A1 | ENSP00000312652 | ENSP00000365686 | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.878 |
| PDZK1 | SLC15A1 | ENSP00000342143 | ENSP00000365686 | PDZ domain containing 1 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.931 |
| PDZK1 | SLC22A5 | ENSP00000342143 | ENSP00000245407 | PDZ domain containing 1 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | 0.943 |
| PRTN3 | SLC15A1 | ENSP00000234347 | ENSP00000365686 | proteinase 3 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.800 |
| SLC15A1 | C10orf10 | ENSP00000365686 | ENSP00000298295 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | chromosome 10 open reading frame 10 | 0.827 |
| SLC15A1 | CDX1 | ENSP00000365686 | ENSP00000231656 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | caudal type homeobox 1; Could play a role in the terminal differentiation of the intestine | 0.874 |
| SLC15A1 | CDX2 | ENSP00000365686 | ENSP00000370408 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | caudal type homeobox 2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine | 0.919 |
| SLC15A1 | IFNG | ENSP00000365686 | ENSP00000229135 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.780 |
| SLC15A1 | LEP | ENSP00000365686 | ENSP00000312652 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | 0.878 |
| SLC15A1 | PDZK1 | ENSP00000365686 | ENSP00000342143 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | PDZ domain containing 1 | 0.931 |
| SLC15A1 | PRTN3 | ENSP00000365686 | ENSP00000234347 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | proteinase 3 | 0.800 |
| SLC15A1 | SLC22A5 | ENSP00000365686 | ENSP00000245407 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | 0.681 |
| SLC15A1 | SLC22A7 | ENSP00000365686 | ENSP00000361666 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.680 |
| SLC15A1 | SLC5A1 | ENSP00000365686 | ENSP00000266088 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | solute carrier family 5 (sodium/glucose cotransporter), member 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules | 0.775 |
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