ABHD12 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ABHD12

abhydrolase domain containing 12 (404 aa)

Predicted Functional Partners:

ABHD6

0.946

MGLL

0.805

CNR1

0.758

VWC2L

0.721

FAAH

0.694

PES1

0.653

ABHD11

0.643

DAGLA

0.563

TMEM246

0.563

ABHD4

0.542

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD11	ABHD12	ENSP00000222800	ENSP00000365725	abhydrolase domain containing 11	abhydrolase domain containing 12	0.643
ABHD11	ABHD6	ENSP00000222800	ENSP00000295962	abhydrolase domain containing 11	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.588
ABHD11	FAAH	ENSP00000222800	ENSP00000243167	abhydrolase domain containing 11	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.464
ABHD11	MGLL	ENSP00000222800	ENSP00000265052	abhydrolase domain containing 11	monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth	0.416
ABHD12	ABHD11	ENSP00000365725	ENSP00000222800	abhydrolase domain containing 12	abhydrolase domain containing 11	0.643
ABHD12	ABHD4	ENSP00000365725	ENSP00000414558	abhydrolase domain containing 12	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	0.542
ABHD12	ABHD6	ENSP00000365725	ENSP00000295962	abhydrolase domain containing 12	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.946
ABHD12	CNR1	ENSP00000365725	ENSP00000358511	abhydrolase domain containing 12	cannabinoid receptor 1 (brain)	0.758
ABHD12	DAGLA	ENSP00000365725	ENSP00000257215	abhydrolase domain containing 12	diacylglycerol lipase, alpha; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses	0.563
ABHD12	FAAH	ENSP00000365725	ENSP00000243167	abhydrolase domain containing 12	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.694
ABHD12	MGLL	ENSP00000365725	ENSP00000265052	abhydrolase domain containing 12	monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth	0.805
ABHD12	PES1	ENSP00000365725	ENSP00000346725	abhydrolase domain containing 12	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.653
ABHD12	TMEM246	ENSP00000365725	ENSP00000363980	abhydrolase domain containing 12	transmembrane protein 246	0.563
ABHD12	VWC2L	ENSP00000365725	ENSP00000308976	abhydrolase domain containing 12	von Willebrand factor C domain containing protein 2-like; May play a role in neurogenesis (By similarity). May play a role in bone differentiation and matrix mineralization (By similarity)	0.721
ABHD4	ABHD12	ENSP00000414558	ENSP00000365725	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	abhydrolase domain containing 12	0.542
ABHD4	ABHD6	ENSP00000414558	ENSP00000295962	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.628
ABHD4	DAGLA	ENSP00000414558	ENSP00000257215	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	diacylglycerol lipase, alpha; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses	0.622
ABHD4	FAAH	ENSP00000414558	ENSP00000243167	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.425
ABHD6	ABHD11	ENSP00000295962	ENSP00000222800	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 11	0.588
ABHD6	ABHD12	ENSP00000295962	ENSP00000365725	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 12	0.946

page 1 of 3

Databases

Neighborhood

Textmining

Cooccurrence

Experiments

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About