node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMT | MTHFD1 | ENSP00000273588 | ENSP00000450560 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.981 |
AMT | MTHFD2 | ENSP00000273588 | ENSP00000377617 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.984 |
AMT | MTHFD2L | ENSP00000273588 | ENSP00000379108 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.985 |
AMT | MTHFR | ENSP00000273588 | ENSP00000365775 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.930 |
AMT | MTR | ENSP00000273588 | ENSP00000355536 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.911 |
AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.985 |
AMT | SHMT2 | ENSP00000273588 | ENSP00000333667 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.988 |
AMT | TYMS | ENSP00000273588 | ENSP00000315644 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.929 |
BHMT | MTHFD1 | ENSP00000274353 | ENSP00000450560 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.763 |
BHMT | MTHFR | ENSP00000274353 | ENSP00000365775 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.937 |
BHMT | MTR | ENSP00000274353 | ENSP00000355536 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.611 |
BHMT | MTRR | ENSP00000274353 | ENSP00000264668 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.722 |
BHMT | SHMT1 | ENSP00000274353 | ENSP00000318868 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.690 |
BHMT | SHMT2 | ENSP00000274353 | ENSP00000333667 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.602 |
BHMT | TYMS | ENSP00000274353 | ENSP00000315644 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.433 |
MTHFD1 | AMT | ENSP00000450560 | ENSP00000273588 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 0.981 |
MTHFD1 | BHMT | ENSP00000450560 | ENSP00000274353 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.763 |
MTHFD1 | MTHFD2 | ENSP00000450560 | ENSP00000377617 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.959 |
MTHFD1 | MTHFD2L | ENSP00000450560 | ENSP00000379108 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.956 |
MTHFD1 | MTHFR | ENSP00000450560 | ENSP00000365775 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.996 |