node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK5RAP2 | CENPJ | ENSP00000343818 | ENSP00000371308 | CDK5 regulatory subunit associated protein 2 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.982 |
CDK5RAP2 | CEP135 | ENSP00000343818 | ENSP00000257287 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | 0.957 |
CDK5RAP2 | CEP57 | ENSP00000343818 | ENSP00000317902 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | 0.908 |
CDK5RAP2 | CEP78 | ENSP00000343818 | ENSP00000365782 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 78kDa | 0.918 |
CDK5RAP2 | CNTRL | ENSP00000343818 | ENSP00000238341 | CDK5 regulatory subunit associated protein 2 | centriolin | 0.907 |
CDK5RAP2 | MAPRE1 | ENSP00000343818 | ENSP00000364721 | CDK5 regulatory subunit associated protein 2 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.912 |
CDK5RAP2 | NEK2 | ENSP00000343818 | ENSP00000355966 | CDK5 regulatory subunit associated protein 2 | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.908 |
CDK5RAP2 | ODF2 | ENSP00000343818 | ENSP00000361882 | CDK5 regulatory subunit associated protein 2 | outer dense fiber of sperm tails 2 | 0.900 |
CDK5RAP2 | PLK4 | ENSP00000343818 | ENSP00000270861 | CDK5 regulatory subunit associated protein 2 | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | 0.969 |
CDK5RAP2 | TUBB4B | ENSP00000343818 | ENSP00000341289 | CDK5 regulatory subunit associated protein 2 | tubulin, beta 4B class IVb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.911 |
CENPJ | CDK5RAP2 | ENSP00000371308 | ENSP00000343818 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | CDK5 regulatory subunit associated protein 2 | 0.982 |
CENPJ | CEP135 | ENSP00000371308 | ENSP00000257287 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | 0.997 |
CENPJ | CEP57 | ENSP00000371308 | ENSP00000317902 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | 0.900 |
CENPJ | CEP78 | ENSP00000371308 | ENSP00000365782 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 78kDa | 0.912 |
CENPJ | CNTRL | ENSP00000371308 | ENSP00000238341 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centriolin | 0.916 |
CENPJ | MAPRE1 | ENSP00000371308 | ENSP00000364721 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.900 |
CENPJ | NEK2 | ENSP00000371308 | ENSP00000355966 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.917 |
CENPJ | ODF2 | ENSP00000371308 | ENSP00000361882 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | outer dense fiber of sperm tails 2 | 0.904 |
CENPJ | PLK4 | ENSP00000371308 | ENSP00000270861 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | 0.994 |
CENPJ | TUBB4B | ENSP00000371308 | ENSP00000341289 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | tubulin, beta 4B class IVb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.911 |