node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENTPD1 | ENTPD3 | ENSP00000360250 | ENSP00000301825 | ectonucleoside triphosphate diphosphohydrolase 1 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | 0.909 |
ENTPD1 | ENTPD6 | ENSP00000360250 | ENSP00000365840 | ectonucleoside triphosphate diphosphohydrolase 1 | ectonucleoside triphosphate diphosphohydrolase 6 (putative); Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5’-diphosphates, nucleoside 5’-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5’-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity) | 0.962 |
ENTPD1 | ENTPD8 | ENSP00000360250 | ENSP00000360561 | ectonucleoside triphosphate diphosphohydrolase 1 | ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP | 0.904 |
ENTPD1 | ITPA | ENSP00000360250 | ENSP00000369456 | ectonucleoside triphosphate diphosphohydrolase 1 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 0.934 |
ENTPD1 | NME1-NME2 | ENSP00000360250 | ENSP00000376886 | ectonucleoside triphosphate diphosphohydrolase 1 | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.911 |
ENTPD1 | NME2 | ENSP00000360250 | ENSP00000376889 | ectonucleoside triphosphate diphosphohydrolase 1 | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.912 |
ENTPD1 | NME5 | ENSP00000360250 | ENSP00000265191 | ectonucleoside triphosphate diphosphohydrolase 1 | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | 0.911 |
ENTPD1 | NME6 | ENSP00000360250 | ENSP00000416658 | ectonucleoside triphosphate diphosphohydrolase 1 | NME/NM23 nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis | 0.911 |
ENTPD1 | NME7 | ENSP00000360250 | ENSP00000356785 | ectonucleoside triphosphate diphosphohydrolase 1 | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.911 |
ENTPD1 | NT5E | ENSP00000360250 | ENSP00000257770 | ectonucleoside triphosphate diphosphohydrolase 1 | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | 0.986 |
ENTPD3 | ENTPD1 | ENSP00000301825 | ENSP00000360250 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | ectonucleoside triphosphate diphosphohydrolase 1 | 0.909 |
ENTPD3 | ENTPD6 | ENSP00000301825 | ENSP00000365840 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | ectonucleoside triphosphate diphosphohydrolase 6 (putative); Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5’-diphosphates, nucleoside 5’-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5’-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity) | 0.962 |
ENTPD3 | ENTPD8 | ENSP00000301825 | ENSP00000360561 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP | 0.906 |
ENTPD3 | ITPA | ENSP00000301825 | ENSP00000369456 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 0.916 |
ENTPD3 | NME1-NME2 | ENSP00000301825 | ENSP00000376886 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.911 |
ENTPD3 | NME2 | ENSP00000301825 | ENSP00000376889 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.911 |
ENTPD3 | NME5 | ENSP00000301825 | ENSP00000265191 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | 0.911 |
ENTPD3 | NME6 | ENSP00000301825 | ENSP00000416658 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | NME/NM23 nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis | 0.911 |
ENTPD3 | NME7 | ENSP00000301825 | ENSP00000356785 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.911 |
ENTPD3 | NT5E | ENSP00000301825 | ENSP00000257770 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | 0.953 |