TRIM39 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TRIM39

tripartite motif containing 39 (518 aa)

Predicted Functional Partners:

TP53

0.800

RPP21

0.796

TRAT1

0.487

TXN

0.483

BBOX1

0.482

C6orf136

0.472

KIFC1

0.456

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBOX1	RPP21	ENSP00000263182	ENSP00000409799	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	ribonuclease P/MRP 21kDa subunit	0.641
BBOX1	TRAT1	ENSP00000263182	ENSP00000295756	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	0.825
BBOX1	TRIM39	ENSP00000263182	ENSP00000365844	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	tripartite motif containing 39	0.482
C6orf136	TRIM39	ENSP00000293604	ENSP00000365844	chromosome 6 open reading frame 136	tripartite motif containing 39	0.472
KIFC1	TRIM39	ENSP00000393963	ENSP00000365844	kinesin family member C1	tripartite motif containing 39	0.456
RPP21	BBOX1	ENSP00000409799	ENSP00000263182	ribonuclease P/MRP 21kDa subunit	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	0.641
RPP21	TRIM39	ENSP00000409799	ENSP00000365844	ribonuclease P/MRP 21kDa subunit	tripartite motif containing 39	0.796
RPP21	TXN	ENSP00000409799	ENSP00000363641	ribonuclease P/MRP 21kDa subunit	thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	0.440
TP53	TRIM39	ENSP00000269305	ENSP00000365844	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	tripartite motif containing 39	0.800
TP53	TXN	ENSP00000269305	ENSP00000363641	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	0.984
TRAT1	BBOX1	ENSP00000295756	ENSP00000263182	T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	0.825
TRAT1	TRIM39	ENSP00000295756	ENSP00000365844	T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	tripartite motif containing 39	0.487
TRIM39	BBOX1	ENSP00000365844	ENSP00000263182	tripartite motif containing 39	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine	0.482
TRIM39	C6orf136	ENSP00000365844	ENSP00000293604	tripartite motif containing 39	chromosome 6 open reading frame 136	0.472
TRIM39	KIFC1	ENSP00000365844	ENSP00000393963	tripartite motif containing 39	kinesin family member C1	0.456
TRIM39	RPP21	ENSP00000365844	ENSP00000409799	tripartite motif containing 39	ribonuclease P/MRP 21kDa subunit	0.796
TRIM39	TP53	ENSP00000365844	ENSP00000269305	tripartite motif containing 39	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.800
TRIM39	TRAT1	ENSP00000365844	ENSP00000295756	tripartite motif containing 39	T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	0.487
TRIM39	TXN	ENSP00000365844	ENSP00000363641	tripartite motif containing 39	thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	0.483
TXN	RPP21	ENSP00000363641	ENSP00000409799	thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	ribonuclease P/MRP 21kDa subunit	0.440

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About