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STRINGSTRING
PDE6B PDE6B NXNL1 NXNL1 COL4A3 COL4A3 SP3 SP3 COL8A2 COL8A2 UBE2I UBE2I VSX1 VSX1 SLC4A11 SLC4A11 IRX5 IRX5 IRX1 IRX1 BHLHE23 BHLHE23
"VSX1" - visual system homeobox 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
VSX1visual system homeobox 1 (365 aa)    
Predicted Functional Partners:
UBE2I
ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) (158 aa)
            score_image   0.865
NXNL1
nucleoredoxin-like 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity) (212 aa)
            score_image   0.814
SLC4A11
solute carrier family 4, sodium borate transporter, member 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sod [...] (918 aa)
            score_image   0.742
COL8A2
collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa)
            score_image   0.682
IRX5
iroquois homeobox 5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12 (483 aa)
            score_image   0.636
SP3
Sp3 transcription factor; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping (781 aa)
            score_image   0.609
IRX1
iroquois homeobox 1 (480 aa)
            score_image   0.568
BHLHE23
basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) (225 aa)
            score_image   0.567
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme (854 aa)
            score_image   0.561
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa)
            score_image   0.531
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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