| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MAP1LC3A | RAB7A | ENSP00000363970 | ENSP00000265062 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.607 |
| MAP1LC3A | TBC1D25 | ENSP00000363970 | ENSP00000365962 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.679 |
| MAP1LC3A | TBC1D2B | ENSP00000363970 | ENSP00000300584 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | TBC1 domain family, member 2B; May act as a GTPase-activating protein (By similarity) | 0.508 |
| MAP1LC3A | TBC1D5 | ENSP00000363970 | ENSP00000402935 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) | 0.758 |
| MAP1LC3B | RAB7A | ENSP00000268607 | ENSP00000265062 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.641 |
| MAP1LC3B | TBC1D25 | ENSP00000268607 | ENSP00000365962 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.731 |
| MAP1LC3B | TBC1D5 | ENSP00000268607 | ENSP00000402935 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) | 0.799 |
| RAB3GAP2 | TBC1D23 | ENSP00000351832 | ENSP00000377700 | RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | TBC1 domain family, member 23 | 0.591 |
| RAB3GAP2 | TBC1D25 | ENSP00000351832 | ENSP00000365962 | RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.640 |
| RAB7A | MAP1LC3A | ENSP00000265062 | ENSP00000363970 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.607 |
| RAB7A | MAP1LC3B | ENSP00000265062 | ENSP00000268607 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.641 |
| RAB7A | TBC1D25 | ENSP00000265062 | ENSP00000365962 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.599 |
| RAB7A | TBC1D5 | ENSP00000265062 | ENSP00000402935 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) | 0.481 |
| RAB7A | VPS26A | ENSP00000265062 | ENSP00000263559 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.868 |
| RAB7A | VPS26B | ENSP00000265062 | ENSP00000281187 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) | 0.843 |
| TBC1D23 | RAB3GAP2 | ENSP00000377700 | ENSP00000351832 | TBC1 domain family, member 23 | RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | 0.591 |
| TBC1D23 | TBC1D25 | ENSP00000377700 | ENSP00000365962 | TBC1 domain family, member 23 | TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.713 |
| TBC1D23 | TBC1D2B | ENSP00000377700 | ENSP00000300584 | TBC1 domain family, member 23 | TBC1 domain family, member 2B; May act as a GTPase-activating protein (By similarity) | 0.576 |
| TBC1D23 | TBC1D5 | ENSP00000377700 | ENSP00000402935 | TBC1 domain family, member 23 | TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) | 0.496 |
| TBC1D23 | TBC1D7 | ENSP00000377700 | ENSP00000348813 | TBC1 domain family, member 23 | TBC1 domain family, member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is u [...] | 0.544 |
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