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RAB6C RAB6C RAB6B RAB6B RAB34 RAB34 LONRF3 LONRF3 RAB6A RAB6A TBC1D8 TBC1D8 RAB41 RAB41 TRAF4 TRAF4 RAB36 RAB36 PDCL3 PDCL3 MFSD9 MFSD9
"TBC1D8" - TBC1 domain family, member 8 (with GRAM domain) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
TBC1D8TBC1 domain family, member 8 (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1140 aa)    
Predicted Functional Partners:
MFSD9
major facilitator superfamily domain containing 9 (474 aa)
            score_image   0.625
PDCL3
phosducin-like 3; Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination (239 aa)
            score_image   0.601
LONRF3
LON peptidase N-terminal domain and ring finger 3 (759 aa)
            score_image   0.583
RAB6C
RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)
        score_image   score_image   0.582
RAB6A
RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
        score_image   score_image   0.582
RAB6B
RAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa)
        score_image   score_image   0.582
RAB41
RAB41, member RAS oncogene family (221 aa)
        score_image   score_image   0.582
RAB34
RAB34, member RAS oncogene family; Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (316 aa)
        score_image   score_image   0.578
RAB36
RAB36, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (333 aa)
        score_image   score_image   0.578
TRAF4
TNF receptor-associated factor 4; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (470 aa)
        score_image       0.571
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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