| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATHL1 | IFITM10 | ENSP00000387185 | ENSP00000344430 | ATH1, acid trehalase-like 1 (yeast) | interferon induced transmembrane protein 10 | 0.778 |
| ATHL1 | SYNDIG1 | ENSP00000387185 | ENSP00000366058 | ATH1, acid trehalase-like 1 (yeast) | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.501 |
| CBLN1 | SYNDIG1 | ENSP00000219197 | ENSP00000366058 | cerebellin 1 precursor; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally a [...] | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.558 |
| DYNLT3 | LIN7B | ENSP00000367841 | ENSP00000221459 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.452 |
| DYNLT3 | SYNDIG1 | ENSP00000367841 | ENSP00000366058 | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.412 |
| FATE1 | SYNDIG1 | ENSP00000359375 | ENSP00000366058 | fetal and adult testis expressed 1 | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.400 |
| GRIA2 | RBM10 | ENSP00000264426 | ENSP00000366829 | glutamate receptor, ionotropic, AMPA 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized [...] | RNA binding motif protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity) | 0.700 |
| GRIA2 | SHISA9 | ENSP00000264426 | ENSP00000454014 | glutamate receptor, ionotropic, AMPA 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized [...] | shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) | 0.791 |
| GRIA2 | SYNDIG1 | ENSP00000264426 | ENSP00000366058 | glutamate receptor, ionotropic, AMPA 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized [...] | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.423 |
| IFITM10 | ATHL1 | ENSP00000344430 | ENSP00000387185 | interferon induced transmembrane protein 10 | ATH1, acid trehalase-like 1 (yeast) | 0.778 |
| IFITM10 | SYNDIG1 | ENSP00000344430 | ENSP00000366058 | interferon induced transmembrane protein 10 | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.414 |
| LIN7B | DYNLT3 | ENSP00000221459 | ENSP00000367841 | lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | dynein, light chain, Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity) | 0.452 |
| LIN7B | SYNDIG1 | ENSP00000221459 | ENSP00000366058 | lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.425 |
| RBM10 | GRIA2 | ENSP00000366829 | ENSP00000264426 | RNA binding motif protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity) | glutamate receptor, ionotropic, AMPA 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized [...] | 0.700 |
| RBM10 | SHISA9 | ENSP00000366829 | ENSP00000454014 | RNA binding motif protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity) | shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) | 0.648 |
| RBM10 | SYNDIG1 | ENSP00000366829 | ENSP00000366058 | RNA binding motif protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity) | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.404 |
| SHISA9 | GRIA2 | ENSP00000454014 | ENSP00000264426 | shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) | glutamate receptor, ionotropic, AMPA 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized [...] | 0.791 |
| SHISA9 | RBM10 | ENSP00000454014 | ENSP00000366829 | shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) | RNA binding motif protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity) | 0.648 |
| SHISA9 | SYNDIG1 | ENSP00000454014 | ENSP00000366058 | shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | 0.507 |
| SYNDIG1 | ATHL1 | ENSP00000366058 | ENSP00000387185 | synapse differentiation inducing 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation (By similarity) | ATH1, acid trehalase-like 1 (yeast) | 0.501 |
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