DNAJC1 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

DNAJC1

DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity) (554 aa)

Predicted Functional Partners:

HSPA5

0.990

SERPINA3

0.977

SEC63

0.865

HSPA8

0.829

HYOU1

0.804

HSPA1A

0.803

HSPA1L

0.801

HSPA6

0.794

HSPA2

0.794

HSPA1B

0.792

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJC1	HSPA1A	ENSP00000366179	ENSP00000364802	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 1A	0.803
DNAJC1	HSPA1B	ENSP00000366179	ENSP00000364801	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 1B	0.792
DNAJC1	HSPA1L	ENSP00000366179	ENSP00000364805	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 1-like	0.801
DNAJC1	HSPA2	ENSP00000366179	ENSP00000247207	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 2; In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage	0.794
DNAJC1	HSPA5	ENSP00000366179	ENSP00000324173	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.990
DNAJC1	HSPA6	ENSP00000366179	ENSP00000310219	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)	0.794
DNAJC1	HSPA8	ENSP00000366179	ENSP00000227378	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex	0.829
DNAJC1	HYOU1	ENSP00000366179	ENSP00000384144	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.804
DNAJC1	SEC63	ENSP00000366179	ENSP00000357998	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane	0.865
DNAJC1	SERPINA3	ENSP00000366179	ENSP00000376793	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.977
HSPA1A	DNAJC1	ENSP00000364802	ENSP00000366179	heat shock 70kDa protein 1A	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	0.803
HSPA1A	HSPA8	ENSP00000364802	ENSP00000227378	heat shock 70kDa protein 1A	heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex	0.571
HSPA1A	HYOU1	ENSP00000364802	ENSP00000384144	heat shock 70kDa protein 1A	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.538
HSPA1A	SEC63	ENSP00000364802	ENSP00000357998	heat shock 70kDa protein 1A	SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane	0.773
HSPA1B	DNAJC1	ENSP00000364801	ENSP00000366179	heat shock 70kDa protein 1B	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	0.792
HSPA1B	HYOU1	ENSP00000364801	ENSP00000384144	heat shock 70kDa protein 1B	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.538
HSPA1B	SEC63	ENSP00000364801	ENSP00000357998	heat shock 70kDa protein 1B	SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane	0.773
HSPA1L	DNAJC1	ENSP00000364805	ENSP00000366179	heat shock 70kDa protein 1-like	DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity)	0.801
HSPA1L	HYOU1	ENSP00000364805	ENSP00000384144	heat shock 70kDa protein 1-like	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.542
HSPA1L	SEC63	ENSP00000364805	ENSP00000357998	heat shock 70kDa protein 1-like	SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane	0.773

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