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STRINGSTRING
UBC UBC PARP14 PARP14 SNX13 SNX13 LRRTM2 LRRTM2 TMC1 TMC1 TMEM2 TMEM2 KREMEN1 KREMEN1 KREMEN2 KREMEN2 PACRGL PACRGL SNX19 SNX19 ABAT ABAT
"TMEM2" - transmembrane protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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Textmining
[Homology]
Score
TMEM2transmembrane protein 2 (1383 aa)    
Predicted Functional Partners:
LRRTM2
leucine rich repeat transmembrane neuronal 2; Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity) (516 aa)
            score_image   0.860
KREMEN2
kringle containing transmembrane protein 2; Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity) (462 aa)
            score_image   0.758
TMC1
transmembrane channel-like 1; Probable ion channel required for the normal function of cochlear hair cells (By similarity) (760 aa)
            score_image   0.757
PACRGL
PARK2 co-regulated-like (221 aa)
            score_image   0.616
KREMEN1
kringle containing transmembrane protein 1 (492 aa)
            score_image   0.562
SNX19
sorting nexin 19; May be involved in several stages of intracellular trafficking (By similarity) (992 aa)
            score_image   0.493
UBC
ubiquitin C (685 aa)
        score_image       0.483
ABAT
4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (500 aa)
            score_image   0.481
SNX13
sorting nexin 13; May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas (957 aa)
            score_image   0.458
PARP14
poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity (1801 aa)
            score_image   0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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