node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | BRAF | ENSP00000366244 | ENSP00000288602 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf murine sarcoma viral oncogene homolog B1 | 0.952 |
ARAF | HRAS | ENSP00000366244 | ENSP00000309845 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.998 |
ARAF | KRAS | ENSP00000366244 | ENSP00000256078 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.980 |
ARAF | MAP2K1 | ENSP00000366244 | ENSP00000302486 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | 0.998 |
ARAF | MAP2K2 | ENSP00000366244 | ENSP00000262948 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) | 0.991 |
ARAF | NRAS | ENSP00000366244 | ENSP00000358548 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.989 |
ARAF | RAP1A | ENSP00000366244 | ENSP00000348786 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.963 |
ARAF | RAP1B | ENSP00000366244 | ENSP00000250559 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | RAP1B, member of RAS oncogene family | 0.954 |
ARAF | RRAS | ENSP00000366244 | ENSP00000246792 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.977 |
ARAF | YWHAZ | ENSP00000366244 | ENSP00000309503 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.936 |
BRAF | ARAF | ENSP00000288602 | ENSP00000366244 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.952 |
BRAF | HRAS | ENSP00000288602 | ENSP00000309845 | v-raf murine sarcoma viral oncogene homolog B1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.999 |
BRAF | KRAS | ENSP00000288602 | ENSP00000256078 | v-raf murine sarcoma viral oncogene homolog B1 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.971 |
BRAF | MAP2K1 | ENSP00000288602 | ENSP00000302486 | v-raf murine sarcoma viral oncogene homolog B1 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | 0.999 |
BRAF | MAP2K2 | ENSP00000288602 | ENSP00000262948 | v-raf murine sarcoma viral oncogene homolog B1 | mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) | 0.999 |
BRAF | NRAS | ENSP00000288602 | ENSP00000358548 | v-raf murine sarcoma viral oncogene homolog B1 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.998 |
BRAF | RAP1A | ENSP00000288602 | ENSP00000348786 | v-raf murine sarcoma viral oncogene homolog B1 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.995 |
BRAF | RAP1B | ENSP00000288602 | ENSP00000250559 | v-raf murine sarcoma viral oncogene homolog B1 | RAP1B, member of RAS oncogene family | 0.972 |
BRAF | RRAS | ENSP00000288602 | ENSP00000246792 | v-raf murine sarcoma viral oncogene homolog B1 | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.947 |
BRAF | YWHAZ | ENSP00000288602 | ENSP00000309503 | v-raf murine sarcoma viral oncogene homolog B1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.991 |