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YWHAZ YWHAZ MAP2K2 MAP2K2 NRAS NRAS RAP1A RAP1A ARAF ARAF RRAS RRAS HRAS HRAS BRAF BRAF RAP1B RAP1B KRAS KRAS MAP2K1 MAP2K1
"ARAF" - v-raf murine sarcoma 3611 viral oncogene homolog in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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protein homology
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ARAFv-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus (606 aa)    
Predicted Functional Partners:
HRAS
v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image score_image score_image   0.998
MAP2K1
mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] (393 aa)
        score_image score_image score_image score_image 0.998
MAP2K2
mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) (400 aa)
        score_image score_image score_image score_image 0.991
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image score_image score_image   0.989
KRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image   score_image   0.980
RRAS
related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton (218 aa)
        score_image score_image score_image   0.977
RAP1A
RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa)
        score_image score_image score_image   0.963
RAP1B
RAP1B, member of RAS oncogene family (184 aa)
        score_image score_image score_image   0.954
BRAF
v-raf murine sarcoma viral oncogene homolog B1 (766 aa)
        score_image   score_image score_image 0.952
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
        score_image   score_image   0.936
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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