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NMRK1 NMRK1 PARP1 PARP1 NNT NNT NADK NADK NMNAT1 NMNAT1 NAMPTL NAMPTL NAPRT1 NAPRT1 NADSYN1 NADSYN1 NMRK2 NMRK2 QPRT QPRT NT5E NT5E
"NMNAT1" - nicotinamide nucleotide adenylyltransferase 1 in Homo sapiens
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NMNAT1nicotinamide nucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails [...] (279 aa)    
Predicted Functional Partners:
NADSYN1
NAD synthetase 1 (706 aa)
score_image         score_image score_image   0.984
NADK
NAD kinase (591 aa)
score_image         score_image score_image   0.969
NAPRT1
nicotinate phosphoribosyltransferase domain containing 1; Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells (538 aa)
score_image         score_image score_image   0.967
QPRT
quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA) (297 aa)
score_image         score_image score_image   0.963
NAMPTL
nicotinamide phosphoribosyltransferase-like (472 aa)
score_image         score_image score_image   0.948
NNT
nicotinamide nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (1086 aa)
      score_image   score_image score_image   0.938
PARP1
poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] (1014 aa)
        score_image   score_image   0.935
NMRK2
nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (230 aa)
          score_image score_image   0.922
NMRK1
nicotinamide riboside kinase 1; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3- deazaguanosine (199 aa)
          score_image score_image   0.908
NT5E
5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities (574 aa)
          score_image score_image   0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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