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STRINGSTRING
PDGFC PDGFC FIP1L1 FIP1L1 REEP6 REEP6 RTN4 RTN4 SNX15 SNX15 RABAC1 RABAC1 SNX1 SNX1 SNX4 SNX4 ANXA7 ANXA7 SNX6 SNX6 SNX3 SNX3
"SNX15" - sorting nexin 15 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SNX15sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (342 aa)    
Predicted Functional Partners:
SNX1
sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (522 aa)
            score_image   0.899
RTN4
reticulon 4 (1192 aa)
        score_image   score_image   0.820
REEP6
receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) (184 aa)
        score_image       0.727
SNX4
sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (450 aa)
            score_image   0.719
SNX3
sorting nexin 3 (162 aa)
            score_image   0.719
RABAC1
Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) (185 aa)
        score_image   score_image   0.714
SNX6
sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation (418 aa)
            score_image   0.687
FIP1L1
FIP1 like 1 (S. cerevisiae) (594 aa)
            score_image   0.684
PDGFC
platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] (345 aa)
            score_image   0.660
ANXA7
annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (488 aa)
            score_image   0.660
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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