node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA7 | SNX1 | ENSP00000362010 | ENSP00000453785 | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.768 |
ANXA7 | SNX15 | ENSP00000362010 | ENSP00000366452 | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.660 |
ANXA7 | SNX3 | ENSP00000362010 | ENSP00000230085 | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | sorting nexin 3 | 0.561 |
ANXA7 | SNX4 | ENSP00000362010 | ENSP00000251775 | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.676 |
ANXA7 | SNX6 | ENSP00000362010 | ENSP00000355217 | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation | 0.592 |
FIP1L1 | PDGFC | ENSP00000336752 | ENSP00000422464 | FIP1 like 1 (S. cerevisiae) | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | 0.668 |
FIP1L1 | SNX15 | ENSP00000336752 | ENSP00000366452 | FIP1 like 1 (S. cerevisiae) | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.684 |
PDGFC | FIP1L1 | ENSP00000422464 | ENSP00000336752 | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | FIP1 like 1 (S. cerevisiae) | 0.668 |
PDGFC | SNX15 | ENSP00000422464 | ENSP00000366452 | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.660 |
RABAC1 | SNX15 | ENSP00000222008 | ENSP00000366452 | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.714 |
REEP6 | RTN4 | ENSP00000233596 | ENSP00000337838 | receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) | reticulon 4 | 0.461 |
REEP6 | SNX15 | ENSP00000233596 | ENSP00000366452 | receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.727 |
RTN4 | REEP6 | ENSP00000337838 | ENSP00000233596 | reticulon 4 | receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) | 0.461 |
RTN4 | SNX1 | ENSP00000337838 | ENSP00000453785 | reticulon 4 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.929 |
RTN4 | SNX15 | ENSP00000337838 | ENSP00000366452 | reticulon 4 | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.820 |
RTN4 | SNX4 | ENSP00000337838 | ENSP00000251775 | reticulon 4 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.447 |
SNX1 | ANXA7 | ENSP00000453785 | ENSP00000362010 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis | 0.768 |
SNX1 | RTN4 | ENSP00000453785 | ENSP00000337838 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | reticulon 4 | 0.929 |
SNX1 | SNX15 | ENSP00000453785 | ENSP00000366452 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN | 0.899 |
SNX1 | SNX4 | ENSP00000453785 | ENSP00000251775 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.876 |