ATG2A protein (Homo sapiens) - STRING network view

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ATG2A

autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (1938 aa)

Predicted Functional Partners:

WIPI1

0.997

WIPI2

0.988

ATG9A

0.976

ULK1

0.807

ULK2

0.794

WDR45

0.790

ULK3

0.748

STK35

0.741

PDIK1L

0.741

BRE

0.740

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG2A	ATG9A	ENSP00000366475	ENSP00000355173	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	autophagy related 9A	0.976
ATG2A	BRE	ENSP00000366475	ENSP00000343412	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.740
ATG2A	PDIK1L	ENSP00000366475	ENSP00000363387	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	PDLIM1 interacting kinase 1 like	0.741
ATG2A	STK35	ENSP00000366475	ENSP00000370891	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	serine/threonine kinase 35	0.741
ATG2A	ULK1	ENSP00000366475	ENSP00000324560	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...]	0.807
ATG2A	ULK2	ENSP00000366475	ENSP00000354877	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	unc-51-like kinase 2 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. [...]	0.794
ATG2A	ULK3	ENSP00000366475	ENSP00000400312	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	unc-51-like kinase 3 (C. elegans); Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well [...]	0.748
ATG2A	WDR45	ENSP00000366475	ENSP00000348848	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	WD repeat domain 45	0.790
ATG2A	WIPI1	ENSP00000366475	ENSP00000262139	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...]	0.997
ATG2A	WIPI2	ENSP00000366475	ENSP00000288828	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P	0.988
ATG9A	ATG2A	ENSP00000355173	ENSP00000366475	autophagy related 9A	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	0.976
ATG9A	PDIK1L	ENSP00000355173	ENSP00000363387	autophagy related 9A	PDLIM1 interacting kinase 1 like	0.883
ATG9A	STK35	ENSP00000355173	ENSP00000370891	autophagy related 9A	serine/threonine kinase 35	0.883
ATG9A	ULK1	ENSP00000355173	ENSP00000324560	autophagy related 9A	unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...]	0.986
ATG9A	ULK2	ENSP00000355173	ENSP00000354877	autophagy related 9A	unc-51-like kinase 2 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. [...]	0.955
ATG9A	ULK3	ENSP00000355173	ENSP00000400312	autophagy related 9A	unc-51-like kinase 3 (C. elegans); Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well [...]	0.916
ATG9A	WDR45	ENSP00000355173	ENSP00000348848	autophagy related 9A	WD repeat domain 45	0.673
ATG9A	WIPI1	ENSP00000355173	ENSP00000262139	autophagy related 9A	WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...]	0.943
ATG9A	WIPI2	ENSP00000355173	ENSP00000288828	autophagy related 9A	WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P	0.936
BRE	ATG2A	ENSP00000343412	ENSP00000366475	brain and reproductive organ-expressed (TNFRSF1A modulator)	autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion	0.740

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