node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | CGB7 | ENSP00000358595 | ENSP00000366493 | glycoprotein hormones, alpha polypeptide | chorionic gonadotropin, beta polypeptide 7 | 0.825 |
CGA | LHCGR | ENSP00000358595 | ENSP00000294954 | glycoprotein hormones, alpha polypeptide | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.967 |
CGB7 | CGA | ENSP00000366493 | ENSP00000358595 | chorionic gonadotropin, beta polypeptide 7 | glycoprotein hormones, alpha polypeptide | 0.825 |
CGB7 | CHGA | ENSP00000366493 | ENSP00000216492 | chorionic gonadotropin, beta polypeptide 7 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.757 |
CGB7 | CHGB | ENSP00000366493 | ENSP00000368244 | chorionic gonadotropin, beta polypeptide 7 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.872 |
CGB7 | EREG | ENSP00000366493 | ENSP00000244869 | chorionic gonadotropin, beta polypeptide 7 | epiregulin; Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis | 0.514 |
CGB7 | ITPR1 | ENSP00000366493 | ENSP00000306253 | chorionic gonadotropin, beta polypeptide 7 | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | 0.846 |
CGB7 | ITPR2 | ENSP00000366493 | ENSP00000370744 | chorionic gonadotropin, beta polypeptide 7 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | 0.809 |
CGB7 | LHCGR | ENSP00000366493 | ENSP00000294954 | chorionic gonadotropin, beta polypeptide 7 | luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.530 |
CGB7 | SCG2 | ENSP00000366493 | ENSP00000304133 | chorionic gonadotropin, beta polypeptide 7 | secretogranin II; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides | 0.812 |
CGB7 | SCG3 | ENSP00000366493 | ENSP00000220478 | chorionic gonadotropin, beta polypeptide 7 | secretogranin III | 0.702 |
CGB7 | SCG5 | ENSP00000366493 | ENSP00000300175 | chorionic gonadotropin, beta polypeptide 7 | secretogranin V (7B2 protein); Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro | 0.566 |
CHGA | CGB7 | ENSP00000216492 | ENSP00000366493 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | chorionic gonadotropin, beta polypeptide 7 | 0.757 |
CHGA | CHGB | ENSP00000216492 | ENSP00000368244 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.897 |
CHGA | SCG2 | ENSP00000216492 | ENSP00000304133 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | secretogranin II; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides | 0.875 |
CHGA | SCG3 | ENSP00000216492 | ENSP00000220478 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | secretogranin III | 0.977 |
CHGA | SCG5 | ENSP00000216492 | ENSP00000300175 | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | secretogranin V (7B2 protein); Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro | 0.581 |
CHGB | CGB7 | ENSP00000368244 | ENSP00000366493 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | chorionic gonadotropin, beta polypeptide 7 | 0.872 |
CHGB | CHGA | ENSP00000368244 | ENSP00000216492 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas | 0.897 |
CHGB | SCG2 | ENSP00000368244 | ENSP00000304133 | chromogranin B (secretogranin 1); Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | secretogranin II; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides | 0.905 |