Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TMEM252 | transmembrane protein 252 (170 aa) | ||||||||||||
Predicted Functional Partners:
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 | PGM5 | phosphoglucomutase 5 (567 aa) |
 |
0.717 | ||||||||||
 | FAM189A2 | family with sequence similarity 189, member A2 (450 aa) |
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0.659 | ||||||||||
 | C9orf135 | chromosome 9 open reading frame 135 (229 aa) |
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0.658 | ||||||||||
 | CBWD3 | COBW domain containing 3 (395 aa) |
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0.658 | ||||||||||
 | SH3BP5L | SH3-binding domain protein 5-like (393 aa) |
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0.608 | ||||||||||
 | FAM122A | family with sequence similarity 122A (287 aa) |
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0.584 | ||||||||||
 | PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 (402 aa) |
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0.570 | ||||||||||
 | PRKACG | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus (351 aa) |
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0.502 | ||||||||||
 | PRLH | prolactin releasing hormone; Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL (87 aa) |
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0.420 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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