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STRINGSTRING
T T TFAP2A TFAP2A PAX6 PAX6 FOXD4L4 FOXD4L4 SOX10 SOX10 MYF5 MYF5 PAX3 PAX3 MITF MITF TBX19 TBX19 PAX7 PAX7 SOX9 SOX9
"FOXD4L4" - forkhead box D4-like 4 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FOXD4L4forkhead box D4-like 4 (416 aa)    
Predicted Functional Partners:
SOX10
SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) (466 aa)
        score_image   score_image   0.806
SOX9
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes (509 aa)
        score_image   score_image   0.806
MYF5
myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (255 aa)
            score_image   0.799
MITF
microphthalmia-associated transcription factor (520 aa)
        score_image   score_image   0.796
TBX19
T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (448 aa)
        score_image   score_image   0.786
T
T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site (435 aa)
        score_image   score_image   0.786
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis [...] (437 aa)
            score_image   0.785
PAX6
paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes (436 aa)
            score_image   0.784
PAX3
paired box 3 (505 aa)
            score_image   0.749
PAX7
paired box 7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation (By similarity) (520 aa)
            score_image   0.749
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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