Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CLN5 | ceroid-lipofuscinosis, neuronal 5 (407 aa) | ||||||||||||
Predicted Functional Partners:
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 | TPP1 | tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) (563 aa) |
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0.960 | ||||||||||
 | ENSG00000261832 | Battenin; CLN3 protein; Uncharacterized protein (360 aa) |
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0.909 | ||||||||||
 | CLN3 | ceroid-lipofuscinosis, neuronal 3 (438 aa) |
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0.909 | ||||||||||
 | CLN6 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant (311 aa) |
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0.898 | ||||||||||
 | CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death (286 aa) |
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0.891 | ||||||||||
 | SOX18 | SRY (sex determining region Y)-box 18; Binds to the consensus sequence 5’-AACAAAG-3’ and is able to trans-activate transcription via this site (By similarity) (384 aa) |
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0.818 | ||||||||||
 | SORT1 | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] (831 aa) |
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0.783 | ||||||||||
 | PPT1 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (306 aa) |
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0.779 | ||||||||||
 | BTF3 | basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription (206 aa) |
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0.759 | ||||||||||
 | MFSD8 | major facilitator superfamily domain containing 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients (Potential) (518 aa) |
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0.751 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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