node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD52 | KLF12 | ENSP00000267116 | ENSP00000366894 | ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.511 |
ANKRD52 | SLMO2 | ENSP00000267116 | ENSP00000348206 | ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates | slowmo homolog 2 (Drosophila) | 0.620 |
CTBP1 | KLF12 | ENSP00000290921 | ENSP00000366894 | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.978 |
DNASE1 | KLF12 | ENSP00000246949 | ENSP00000366894 | deoxyribonuclease I; Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity) | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.515 |
GRHL2 | KLF12 | ENSP00000251808 | ENSP00000366894 | grainyhead-like 2 (Drosophila); May function as a transcription factor | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.800 |
KDM2A | KLF12 | ENSP00000432786 | ENSP00000366894 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.501 |
KLF12 | ANKRD52 | ENSP00000366894 | ENSP00000267116 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates | 0.511 |
KLF12 | CTBP1 | ENSP00000366894 | ENSP00000290921 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity | 0.978 |
KLF12 | DNASE1 | ENSP00000366894 | ENSP00000246949 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | deoxyribonuclease I; Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity) | 0.515 |
KLF12 | GRHL2 | ENSP00000366894 | ENSP00000251808 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | grainyhead-like 2 (Drosophila); May function as a transcription factor | 0.800 |
KLF12 | KDM2A | ENSP00000366894 | ENSP00000432786 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
KLF12 | SLMO2 | ENSP00000366894 | ENSP00000348206 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | slowmo homolog 2 (Drosophila) | 0.506 |
KLF12 | TAF1 | ENSP00000366894 | ENSP00000276072 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.720 |
KLF12 | TAF1L | ENSP00000366894 | ENSP00000418379 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | 0.696 |
KLF12 | TFAP2A | ENSP00000366894 | ENSP00000368924 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis [...] | 0.742 |
KLF12 | XRN1 | ENSP00000366894 | ENSP00000264951 | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.543 |
SLMO2 | ANKRD52 | ENSP00000348206 | ENSP00000267116 | slowmo homolog 2 (Drosophila) | ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates | 0.620 |
SLMO2 | KLF12 | ENSP00000348206 | ENSP00000366894 | slowmo homolog 2 (Drosophila) | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.506 |
TAF1 | KLF12 | ENSP00000276072 | ENSP00000366894 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | Kruppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter | 0.720 |
TAF1 | TAF1L | ENSP00000276072 | ENSP00000418379 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | 0.718 |