node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBXL19 | ZNF133 | ENSP00000369666 | ENSP00000366899 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.501 |
HTN3 | ZNF133 | ENSP00000432561 | ENSP00000366899 | histatin 3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.610 |
KDM2A | ZNF133 | ENSP00000432786 | ENSP00000366899 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.501 |
KDM2B | ZNF133 | ENSP00000366271 | ENSP00000366899 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.501 |
LGALS4 | ZNF133 | ENSP00000302100 | ENSP00000366899 | lectin, galactoside-binding, soluble, 4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.561 |
PTPN23 | ZNF133 | ENSP00000265562 | ENSP00000366899 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.476 |
SLC24A3 | SLC4A11 | ENSP00000333519 | ENSP00000369399 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity) | solute carrier family 4, sodium borate transporter, member 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sod [...] | 0.538 |
SLC24A3 | ZNF133 | ENSP00000333519 | ENSP00000366899 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity) | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.619 |
SLC4A11 | SLC24A3 | ENSP00000369399 | ENSP00000333519 | solute carrier family 4, sodium borate transporter, member 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sod [...] | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity) | 0.538 |
SLC4A11 | ZNF133 | ENSP00000369399 | ENSP00000366899 | solute carrier family 4, sodium borate transporter, member 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sod [...] | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.518 |
TRIM28 | ZNF133 | ENSP00000253024 | ENSP00000366899 | tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.576 |
XRN1 | ZNF133 | ENSP00000264951 | ENSP00000366899 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | 0.543 |
ZNF133 | FBXL19 | ENSP00000366899 | ENSP00000369666 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF133 | HTN3 | ENSP00000366899 | ENSP00000432561 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | histatin 3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | 0.610 |
ZNF133 | KDM2A | ENSP00000366899 | ENSP00000432786 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF133 | KDM2B | ENSP00000366899 | ENSP00000366271 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF133 | LGALS4 | ENSP00000366899 | ENSP00000302100 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | lectin, galactoside-binding, soluble, 4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions | 0.561 |
ZNF133 | PTPN23 | ENSP00000366899 | ENSP00000265562 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |
ZNF133 | SLC24A3 | ENSP00000366899 | ENSP00000333519 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity) | 0.619 |
ZNF133 | SLC4A11 | ENSP00000366899 | ENSP00000369399 | zinc finger protein 133; May be involved in transcriptional regulation as a repressor | solute carrier family 4, sodium borate transporter, member 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sod [...] | 0.518 |