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ADH1B ADH1B ADH6 ADH6 ADH1A ADH1A ACSS2 ACSS2 ACSS1 ACSS1 ADH4 ADH4 ALDH1B1 ALDH1B1 EHHADH EHHADH ADH7 ADH7 ABAT ABAT HIBADH HIBADH
"ALDH1B1" - aldehyde dehydrogenase 1 family, member B1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ALDH1B1aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)    
Predicted Functional Partners:
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa)
          score_image score_image   0.976
ADH6
alcohol dehydrogenase 6 (class V) (375 aa)
          score_image score_image   0.975
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa)
          score_image score_image   0.974
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide (375 aa)
          score_image score_image   0.971
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
          score_image score_image   0.971
ACSS1
acyl-CoA synthetase short-chain family member 1 (689 aa)
      score_image score_image score_image score_image   0.961
ACSS2
acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation (714 aa)
      score_image score_image score_image score_image   0.957
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
          score_image score_image   0.951
ABAT
4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (500 aa)
score_image     score_image score_image score_image score_image   0.947
HIBADH
3-hydroxyisobutyrate dehydrogenase (336 aa)
score_image     score_image   score_image score_image   0.941
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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