Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC36A3 | solute carrier family 36 (proton/amino acid symporter), member 3 (511 aa) | ||||||||||||
Predicted Functional Partners:
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 | ACLY | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa) |
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0.591 | |||||||||
 | PTX4 | pentraxin 4, long (473 aa) |
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0.561 | ||||||||||
 | SLC38A1 | solute carrier family 38, member 1; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1-1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA (487 aa) |
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0.558 | |||||||||
 | DPYD | dihydropyrimidine dehydrogenase (1025 aa) |
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0.557 | |||||||||
 | SLC38A5 | solute carrier family 38, member 5; Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH- sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (472 aa) |
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0.549 | |||||||||
 | SLC6A18 | solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) (628 aa) |
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0.548 | ||||||||||
 | SLC38A10 | solute carrier family 38, member 10; Putative sodium-dependent amino acid/proton antiporter (By similarity) (1119 aa) |
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0.542 | |||||||||
 | SLC38A7 | solute carrier family 38, member 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity) (462 aa) |
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0.542 | |||||||||
 | SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine (592 aa) |
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0.521 | ||||||||||
 | SLC6A19 | solute carrier family 6 (neutral amino acid transporter), member 19; Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) (634 aa) |
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0.521 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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