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DDB1 DDB1 DCAF11 DCAF11 DCAF10 DCAF10 DCAF16 DCAF16 CUL4B CUL4B H326 H326 DCAF13 DCAF13 ERCC8 ERCC8 CUL4A CUL4A DCAF12 DCAF12 DCAF5 DCAF5
"DCAF10" - DDB1 and CUL4 associated factor 10 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining edge
textmining
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co-expression
homology edge
protein homology
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Score
DCAF10DDB1 and CUL4 associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (559 aa)    
Predicted Functional Partners:
DCAF12
DDB1 and CUL4 associated factor 12 (453 aa)
          score_image score_image   0.965
DCAF5
DDB1 and CUL4 associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (942 aa)
          score_image score_image   0.964
DDB1
damage-specific DNA binding protein 1, 127kDa; Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which [...] (1140 aa)
        score_image score_image     0.953
CUL4A
cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] (759 aa)
        score_image score_image score_image   0.937
DCAF11
DDB1 and CUL4 associated factor 11 (546 aa)
          score_image score_image score_image 0.924
ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] (396 aa)
          score_image score_image   0.916
DCAF13
DDB1 and CUL4 associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (597 aa)
          score_image score_image   0.907
H326
DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (751 aa)
          score_image     0.900
CUL4B
cullin 4B (913 aa)
          score_image     0.900
DCAF16
DDB1 and CUL4 associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (216 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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