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HIST1H2AI HIST1H2AI H2AFZ H2AFZ HIST1H2AG HIST1H2AG HIST1H3E HIST1H3E HIST1H4F HIST1H4F ASF1A ASF1A HIST1H2AB HIST1H2AB CENPA CENPA H3F3A H3F3A HIST1H2AK HIST1H2AK HIST1H2AL HIST1H2AL
"HIST1H4F" - histone cluster 1, H4f in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
HIST1H4Fhistone cluster 1, H4f (103 aa)    
Predicted Functional Partners:
H3F3A
H3 histone, family 3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a centra [...] (136 aa)
      score_image score_image   score_image   0.909
CENPA
centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (140 aa)
      score_image score_image   score_image   0.905
H2AFZ
H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] (128 aa)
      score_image score_image   score_image   0.900
HIST1H2AI
histone cluster 1, H2ai (130 aa)
  score_image   score_image score_image   score_image   0.897
HIST1H2AK
histone cluster 1, H2ak (130 aa)
  score_image   score_image score_image   score_image   0.896
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae); Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (204 aa)
        score_image   score_image   0.896
HIST1H3E
histone cluster 1, H3e (136 aa)
      score_image score_image   score_image   0.892
HIST1H2AL
histone cluster 1, H2al (130 aa)
  score_image   score_image score_image   score_image   0.891
HIST1H2AG
histone cluster 1, H2ag (130 aa)
  score_image   score_image score_image   score_image   0.884
HIST1H2AB
histone cluster 1, H2ab (130 aa)
  score_image   score_image score_image   score_image   0.882
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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