node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATRX | CBX3 | ENSP00000362441 | ENSP00000336687 | alpha thalassemia/mental retardation syndrome X-linked | chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | 0.474 |
ATRX | DNMT3A | ENSP00000362441 | ENSP00000264709 | alpha thalassemia/mental retardation syndrome X-linked | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | 0.546 |
ATRX | DNMT3L | ENSP00000362441 | ENSP00000270172 | alpha thalassemia/mental retardation syndrome X-linked | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | 0.512 |
ATRX | TRDMT1 | ENSP00000362441 | ENSP00000367030 | alpha thalassemia/mental retardation syndrome X-linked | tRNA aspartic acid methyltransferase 1; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) | 0.572 |
CBX3 | ATRX | ENSP00000336687 | ENSP00000362441 | chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | alpha thalassemia/mental retardation syndrome X-linked | 0.474 |
CBX3 | DNMT3B | ENSP00000336687 | ENSP00000328547 | chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | DNA (cytosine-5-)-methyltransferase 3 beta | 0.866 |
CBX3 | TRDMT1 | ENSP00000336687 | ENSP00000367030 | chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | tRNA aspartic acid methyltransferase 1; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) | 0.669 |
DNMT3A | ATRX | ENSP00000264709 | ENSP00000362441 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | alpha thalassemia/mental retardation syndrome X-linked | 0.546 |
DNMT3A | DNMT3B | ENSP00000264709 | ENSP00000328547 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | DNA (cytosine-5-)-methyltransferase 3 beta | 0.996 |
DNMT3A | DNMT3L | ENSP00000264709 | ENSP00000270172 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | 0.998 |
DNMT3A | MBD4 | ENSP00000264709 | ENSP00000249910 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | methyl-CpG binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G-T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G-U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein | 0.628 |
DNMT3A | TRDMT1 | ENSP00000264709 | ENSP00000367030 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | tRNA aspartic acid methyltransferase 1; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) | 0.798 |
DNMT3B | CBX3 | ENSP00000328547 | ENSP00000336687 | DNA (cytosine-5-)-methyltransferase 3 beta | chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | 0.866 |
DNMT3B | DNMT3A | ENSP00000328547 | ENSP00000264709 | DNA (cytosine-5-)-methyltransferase 3 beta | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | 0.996 |
DNMT3B | DNMT3L | ENSP00000328547 | ENSP00000270172 | DNA (cytosine-5-)-methyltransferase 3 beta | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | 0.967 |
DNMT3B | MBD4 | ENSP00000328547 | ENSP00000249910 | DNA (cytosine-5-)-methyltransferase 3 beta | methyl-CpG binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G-T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G-U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein | 0.865 |
DNMT3B | TRDMT1 | ENSP00000328547 | ENSP00000367030 | DNA (cytosine-5-)-methyltransferase 3 beta | tRNA aspartic acid methyltransferase 1; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) | 0.832 |
DNMT3L | ATRX | ENSP00000270172 | ENSP00000362441 | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | alpha thalassemia/mental retardation syndrome X-linked | 0.512 |
DNMT3L | DNMT3A | ENSP00000270172 | ENSP00000264709 | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | 0.998 |
DNMT3L | DNMT3B | ENSP00000270172 | ENSP00000328547 | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 | DNA (cytosine-5-)-methyltransferase 3 beta | 0.967 |