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HIST1H2AI HIST1H2AI HIST1H2AM HIST1H2AM HIST1H2BC HIST1H2BC HIST1H2AG HIST1H2AG HIST1H2BF HIST1H2BF HIST1H4C HIST1H4C HIST1H2BG HIST1H2BG HIST1H2AB HIST1H2AB HIST1H2BE HIST1H2BE HIST1H2AK HIST1H2AK HIST1H2AL HIST1H2AL
"HIST1H4C" - histone cluster 1, H4c in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIST1H4Chistone cluster 1, H4c (103 aa)    
Predicted Functional Partners:
HIST1H2AI
histone cluster 1, H2ai (130 aa)
  score_image   score_image score_image   score_image   0.884
HIST1H2AK
histone cluster 1, H2ak (130 aa)
  score_image   score_image score_image   score_image   0.884
HIST1H2AL
histone cluster 1, H2al (130 aa)
  score_image   score_image score_image   score_image   0.884
HIST1H2AG
histone cluster 1, H2ag (130 aa)
  score_image   score_image score_image   score_image   0.877
HIST1H2AB
histone cluster 1, H2ab (130 aa)
  score_image   score_image score_image   score_image   0.875
HIST1H2AM
histone cluster 1, H2am; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (130 aa)
  score_image   score_image score_image   score_image   0.862
HIST1H2BC
histone cluster 1, H2bc (126 aa)
      score_image score_image   score_image   0.859
HIST1H2BE
histone cluster 1, H2be (126 aa)
      score_image score_image   score_image   0.859
HIST1H2BG
histone cluster 1, H2bg (126 aa)
      score_image score_image   score_image   0.859
HIST1H2BF
histone cluster 1, H2bf (126 aa)
      score_image score_image   score_image   0.856
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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