node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATOH1 | HES2 | ENSP00000302216 | ENSP00000367065 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | 0.496 |
ATOH1 | HEY1 | ENSP00000302216 | ENSP00000338272 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | hairy/enhancer-of-split related with YRPW motif 1; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 | 0.568 |
ATOH1 | NOTCH1 | ENSP00000302216 | ENSP00000277541 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.967 |
ATOH1 | NOTCH2 | ENSP00000302216 | ENSP00000256646 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | notch 2 | 0.729 |
ATOH1 | NOTCH3 | ENSP00000302216 | ENSP00000263388 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.701 |
ATOH1 | NOTCH4 | ENSP00000302216 | ENSP00000364163 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | notch 4 | 0.648 |
ATOH1 | TCF12 | ENSP00000302216 | ENSP00000331057 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.928 |
ATOH1 | TCF3 | ENSP00000302216 | ENSP00000262965 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.925 |
ATOH1 | TCF4 | ENSP00000302216 | ENSP00000346440 | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | transcription factor 4 | 0.988 |
HES2 | ATOH1 | ENSP00000367065 | ENSP00000302216 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) | 0.496 |
HES2 | HES3 | ENSP00000367065 | ENSP00000367130 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | hairy and enhancer of split 3 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | 0.910 |
HES2 | HEY1 | ENSP00000367065 | ENSP00000338272 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | hairy/enhancer-of-split related with YRPW motif 1; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 | 0.563 |
HES2 | NOTCH1 | ENSP00000367065 | ENSP00000277541 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.621 |
HES2 | NOTCH2 | ENSP00000367065 | ENSP00000256646 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | notch 2 | 0.605 |
HES2 | NOTCH3 | ENSP00000367065 | ENSP00000263388 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.572 |
HES2 | NOTCH4 | ENSP00000367065 | ENSP00000364163 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | notch 4 | 0.568 |
HES2 | TCF12 | ENSP00000367065 | ENSP00000331057 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.501 |
HES2 | TCF3 | ENSP00000367065 | ENSP00000262965 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.519 |
HES2 | TCF4 | ENSP00000367065 | ENSP00000346440 | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | transcription factor 4 | 0.518 |
HES3 | HES2 | ENSP00000367130 | ENSP00000367065 | hairy and enhancer of split 3 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | hairy and enhancer of split 2 (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity) | 0.910 |