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SLC47A1 SLC47A1 ABCC2 ABCC2 YRDC YRDC ABCC4 ABCC4 SLCO1B1 SLCO1B1 SLC22A6 SLC22A6 RSC1A1 RSC1A1 SLC26A6 SLC26A6 SLCO1A2 SLCO1A2 SLC6A2 SLC6A2 SLC17A1 SLC17A1
"SLC22A6" - solute carrier family 22 (organic anion transporter), member 6 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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Score
SLC22A6solute carrier family 22 (organic anion transporter), member 6 (563 aa)    
Predicted Functional Partners:
SLC26A6
solute carrier family 26, member 6; Does not seem to be involved in anion transport (759 aa)
            score_image   0.905
ABCC4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification (1325 aa)
            score_image   0.783
YRDC
yrdC domain containing (E. coli); May regulate the activity of some transporters (By similarity) (279 aa)
            score_image   0.750
RSC1A1
regulatory solute carrier protein, family 1, member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (617 aa)
            score_image   0.746
SLCO1A2
solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin (670 aa)
            score_image   0.742
SLCO1B1
solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver (691 aa)
            score_image   0.737
SLC17A1
solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (467 aa)
            score_image   0.722
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa)
            score_image   0.705
SLC47A1
solute carrier family 47, member 1; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4’-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (570 aa)
            score_image   0.686
SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals (628 aa)
            score_image   0.683
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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