node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC2 | SLC22A6 | ENSP00000359478 | ENSP00000367102 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 22 (organic anion transporter), member 6 | 0.705 |
ABCC2 | SLC26A6 | ENSP00000359478 | ENSP00000378920 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.687 |
ABCC2 | SLC47A1 | ENSP00000359478 | ENSP00000270570 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 47, member 1; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4’-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes | 0.453 |
ABCC2 | SLCO1A2 | ENSP00000359478 | ENSP00000305974 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.745 |
ABCC2 | SLCO1B1 | ENSP00000359478 | ENSP00000256958 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.886 |
ABCC4 | SLC17A1 | ENSP00000366084 | ENSP00000244527 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | 0.568 |
ABCC4 | SLC22A6 | ENSP00000366084 | ENSP00000367102 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 22 (organic anion transporter), member 6 | 0.783 |
ABCC4 | SLC26A6 | ENSP00000366084 | ENSP00000378920 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.691 |
ABCC4 | SLC47A1 | ENSP00000366084 | ENSP00000270570 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 47, member 1; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4’-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes | 0.535 |
ABCC4 | SLCO1A2 | ENSP00000366084 | ENSP00000305974 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.738 |
ABCC4 | SLCO1B1 | ENSP00000366084 | ENSP00000256958 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.739 |
RSC1A1 | SLC22A6 | ENSP00000341963 | ENSP00000367102 | regulatory solute carrier protein, family 1, member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network | solute carrier family 22 (organic anion transporter), member 6 | 0.746 |
RSC1A1 | SLC6A2 | ENSP00000341963 | ENSP00000219833 | regulatory solute carrier protein, family 1, member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.750 |
RSC1A1 | YRDC | ENSP00000341963 | ENSP00000362135 | regulatory solute carrier protein, family 1, member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network | yrdC domain containing (E. coli); May regulate the activity of some transporters (By similarity) | 0.803 |
SLC17A1 | ABCC4 | ENSP00000244527 | ENSP00000366084 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | 0.568 |
SLC17A1 | SLC22A6 | ENSP00000244527 | ENSP00000367102 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier family 22 (organic anion transporter), member 6 | 0.722 |
SLC17A1 | SLC26A6 | ENSP00000244527 | ENSP00000378920 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.580 |
SLC17A1 | SLCO1A2 | ENSP00000244527 | ENSP00000305974 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.523 |
SLC17A1 | SLCO1B1 | ENSP00000244527 | ENSP00000256958 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.429 |
SLC22A6 | ABCC2 | ENSP00000367102 | ENSP00000359478 | solute carrier family 22 (organic anion transporter), member 6 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | 0.705 |