Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | GLIPR2 | GLI pathogenesis-related 2 (154 aa) | ||||||||||||
Predicted Functional Partners:
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 | CAV1 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (178 aa) |
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0.905 | |||||||||
 | GLIPR1L1 | GLI pathogenesis-related 1 like 1 (233 aa) |
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0.817 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.803 | ||||||||||
 | GLIPR1 | GLI pathogenesis-related 1 (266 aa) |
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0.769 | |||||||||
 | CDV3 | CDV3 homolog (mouse) (258 aa) |
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0.667 | |||||||||
 | PI15 | peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (258 aa) |
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0.598 | |||||||||
 | BECN1 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus (450 aa) |
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0.589 | |||||||||
 | CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 (500 aa) |
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0.538 | ||||||||||
 | CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity) (497 aa) |
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0.529 | ||||||||||
 | CLCA1 | chloride channel accessory 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (914 aa) |
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0.524 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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