CKAP4 protein (Homo sapiens) - STRING network view

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CKAP4

cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF (602 aa)

Predicted Functional Partners:

UBC

0.912

ZDHHC2

0.876

DICER1

0.801

USP50

0.740

PLAT

0.581

ADRA1D

0.556

NKX3-1

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1D	CKAP4	ENSP00000368766	ENSP00000367265	adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.556
CKAP4	ADRA1D	ENSP00000367265	ENSP00000368766	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium	0.556
CKAP4	DICER1	ENSP00000367265	ENSP00000343745	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	0.801
CKAP4	NKX3-1	ENSP00000367265	ENSP00000370253	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells	0.529
CKAP4	PLAT	ENSP00000367265	ENSP00000220809	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	plasminogen activator, tissue	0.581
CKAP4	UBC	ENSP00000367265	ENSP00000344818	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	ubiquitin C	0.912
CKAP4	USP50	ENSP00000367265	ENSP00000434676	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
CKAP4	ZDHHC2	ENSP00000367265	ENSP00000262096	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)	0.876
DICER1	CKAP4	ENSP00000343745	ENSP00000367265	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.801
DICER1	UBC	ENSP00000343745	ENSP00000344818	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	ubiquitin C	0.697
NKX3-1	CKAP4	ENSP00000370253	ENSP00000367265	NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.529
PLAT	CKAP4	ENSP00000220809	ENSP00000367265	plasminogen activator, tissue	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.581
UBC	CKAP4	ENSP00000344818	ENSP00000367265	ubiquitin C	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.912
UBC	DICER1	ENSP00000344818	ENSP00000343745	ubiquitin C	dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...]	0.697
USP50	CKAP4	ENSP00000434676	ENSP00000367265	ubiquitin specific peptidase 50; Has no peptidase activity	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.740
ZDHHC2	CKAP4	ENSP00000262096	ENSP00000367265	zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity)	cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF	0.876

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