FUNDC1 protein (Homo sapiens) - STRING network view

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FUNDC1

FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control (155 aa)

Predicted Functional Partners:

ULK1

0.859

PGAM5

0.836

EFHC2

0.779

MAP1LC3B

0.595

LRSAM1

0.541

SLC25A46

0.531

MAP1LC3A

0.500

AMBRA1

0.489

NEDD8

0.483

UBC

0.483

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	FUNDC1	ENSP00000318313	ENSP00000367284	autophagy/beclin-1 regulator 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.489
AMBRA1	MAP1LC3B	ENSP00000318313	ENSP00000268607	autophagy/beclin-1 regulator 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)	microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes)	0.455
AMBRA1	UBC	ENSP00000318313	ENSP00000344818	autophagy/beclin-1 regulator 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)	ubiquitin C	0.982
AMBRA1	ULK1	ENSP00000318313	ENSP00000324560	autophagy/beclin-1 regulator 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)	unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...]	0.988
EFHC2	FUNDC1	ENSP00000333823	ENSP00000367284	EF-hand domain (C-terminal) containing 2	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.779
FUNDC1	AMBRA1	ENSP00000367284	ENSP00000318313	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	autophagy/beclin-1 regulator 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)	0.489
FUNDC1	EFHC2	ENSP00000367284	ENSP00000333823	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	EF-hand domain (C-terminal) containing 2	0.779
FUNDC1	LRSAM1	ENSP00000367284	ENSP00000300417	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos	0.541
FUNDC1	MAP1LC3A	ENSP00000367284	ENSP00000363970	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	0.500
FUNDC1	MAP1LC3B	ENSP00000367284	ENSP00000268607	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes)	0.595
FUNDC1	NEDD8	ENSP00000367284	ENSP00000250495	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins	0.483
FUNDC1	PGAM5	ENSP00000367284	ENSP00000438465	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore	0.836
FUNDC1	SLC25A46	ENSP00000367284	ENSP00000348211	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	solute carrier family 25, member 46	0.531
FUNDC1	UBC	ENSP00000367284	ENSP00000344818	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	ubiquitin C	0.483
FUNDC1	ULK1	ENSP00000367284	ENSP00000324560	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...]	0.859
LRSAM1	FUNDC1	ENSP00000300417	ENSP00000367284	leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.541
LRSAM1	UBC	ENSP00000300417	ENSP00000344818	leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos	ubiquitin C	0.945
MAP1LC3A	FUNDC1	ENSP00000363970	ENSP00000367284	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.500
MAP1LC3A	UBC	ENSP00000363970	ENSP00000344818	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	ubiquitin C	0.945
MAP1LC3A	ULK1	ENSP00000363970	ENSP00000324560	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...]	0.980

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