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STRINGSTRING
FANCC FANCC TMEM27 TMEM27 BCL2L1 BCL2L1 DNAJC15 DNAJC15 MYC MYC ACBD7 ACBD7 FGF2 FGF2 BCL2 BCL2 ICAM1 ICAM1 ACACA ACACA ACACB ACACB
"ACBD7" - acyl-CoA binding domain containing 7 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ACBD7acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters (88 aa)    
Predicted Functional Partners:
BCL2
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (239 aa)
            score_image   0.676
MYC
v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa)
            score_image   0.674
BCL2L1
BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (233 aa)
            score_image   0.633
FGF2
fibroblast growth factor 2 (basic) (288 aa)
            score_image   0.629
DNAJC15
DnaJ (Hsp40) homolog, subfamily C, member 15 (150 aa)
            score_image   0.623
TMEM27
transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication (222 aa)
            score_image   0.619
FANCC
Fanconi anemia, complementation group C; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (558 aa)
            score_image   0.619
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
            score_image   0.565
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
            score_image   0.539
ICAM1
intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus (532 aa)
            score_image   0.530
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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