node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | ACBD7 | ENSP00000344789 | ENSP00000367453 | acetyl-CoA carboxylase alpha | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | 0.539 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | ACBD7 | ENSP00000341044 | ENSP00000367453 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | 0.565 |
ACBD7 | ACACA | ENSP00000367453 | ENSP00000344789 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | acetyl-CoA carboxylase alpha | 0.539 |
ACBD7 | ACACB | ENSP00000367453 | ENSP00000341044 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.565 |
ACBD7 | BCL2 | ENSP00000367453 | ENSP00000329623 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | 0.676 |
ACBD7 | BCL2L1 | ENSP00000367453 | ENSP00000302564 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.633 |
ACBD7 | DNAJC15 | ENSP00000367453 | ENSP00000368523 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.623 |
ACBD7 | FANCC | ENSP00000367453 | ENSP00000289081 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | Fanconi anemia, complementation group C; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 | 0.619 |
ACBD7 | FGF2 | ENSP00000367453 | ENSP00000264498 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | fibroblast growth factor 2 (basic) | 0.629 |
ACBD7 | ICAM1 | ENSP00000367453 | ENSP00000264832 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus | 0.530 |
ACBD7 | MYC | ENSP00000367453 | ENSP00000367207 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.674 |
ACBD7 | TMEM27 | ENSP00000367453 | ENSP00000369699 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.619 |
BCL2 | ACBD7 | ENSP00000329623 | ENSP00000367453 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | 0.676 |
BCL2 | BCL2L1 | ENSP00000329623 | ENSP00000302564 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.996 |
BCL2 | FGF2 | ENSP00000329623 | ENSP00000264498 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | fibroblast growth factor 2 (basic) | 0.930 |
BCL2 | ICAM1 | ENSP00000329623 | ENSP00000264832 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus | 0.673 |
BCL2 | MYC | ENSP00000329623 | ENSP00000367207 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.998 |
BCL2L1 | ACBD7 | ENSP00000302564 | ENSP00000367453 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | 0.633 |