node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT13 | DCDC2 | ENSP00000230048 | ENSP00000367715 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.751 |
ACOT13 | DYX1C1 | ENSP00000230048 | ENSP00000323275 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.515 |
ACOT13 | KIAA0319 | ENSP00000230048 | ENSP00000367459 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | KIAA0319 | 0.815 |
ACOT13 | TDP2 | ENSP00000230048 | ENSP00000367440 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | tyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5’-phosphodiester bond, giving rise to DNA with a free 5’ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5’- phosphoglycolates on protruding 5’ ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5’-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, crea [...] | 0.816 |
ATP2C2 | CMIP | ENSP00000262429 | ENSP00000446100 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | 0.787 |
ATP2C2 | DCDC2 | ENSP00000262429 | ENSP00000367715 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.626 |
ATP2C2 | DYX1C1 | ENSP00000262429 | ENSP00000323275 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.555 |
ATP2C2 | GCFC2 | ENSP00000262429 | ENSP00000318690 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.692 |
ATP2C2 | KIAA0319 | ENSP00000262429 | ENSP00000367459 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | KIAA0319 | 0.585 |
ATP2C2 | MRPL19 | ENSP00000262429 | ENSP00000377486 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | mitochondrial ribosomal protein L19 | 0.691 |
CMIP | ATP2C2 | ENSP00000446100 | ENSP00000262429 | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | 0.787 |
CMIP | DCDC2 | ENSP00000446100 | ENSP00000367715 | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.568 |
CMIP | DYX1C1 | ENSP00000446100 | ENSP00000323275 | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.484 |
CMIP | KIAA0319 | ENSP00000446100 | ENSP00000367459 | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | KIAA0319 | 0.586 |
CMIP | MRPL19 | ENSP00000446100 | ENSP00000377486 | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | mitochondrial ribosomal protein L19 | 0.661 |
DCDC2 | ACOT13 | ENSP00000367715 | ENSP00000230048 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | 0.751 |
DCDC2 | ATP2C2 | ENSP00000367715 | ENSP00000262429 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | 0.626 |
DCDC2 | CMIP | ENSP00000367715 | ENSP00000446100 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | c-Maf inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor | 0.568 |
DCDC2 | DYX1C1 | ENSP00000367715 | ENSP00000323275 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.852 |
DCDC2 | GCFC2 | ENSP00000367715 | ENSP00000318690 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.818 |