node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJB13 | MEIG1 | ENSP00000344431 | ENSP00000367486 | DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.504 |
FHL5 | MEIG1 | ENSP00000326022 | ENSP00000367486 | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.499 |
MEIG1 | DNAJB13 | ENSP00000367486 | ENSP00000344431 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis | 0.504 |
MEIG1 | FHL5 | ENSP00000367486 | ENSP00000326022 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | 0.499 |
MEIG1 | NXF3 | ENSP00000367486 | ENSP00000378504 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | 0.665 |
MEIG1 | POLR2J | ENSP00000367486 | ENSP00000292614 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity) | 0.555 |
MEIG1 | RNF17 | ENSP00000367486 | ENSP00000255324 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.579 |
MEIG1 | SPAG16 | ENSP00000367486 | ENSP00000332592 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | sperm associated antigen 16; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity) | 0.991 |
MEIG1 | SPAG6 | ENSP00000367486 | ENSP00000365811 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | sperm associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility (By similarity) | 0.898 |
MEIG1 | SPRYD7 | ENSP00000367486 | ENSP00000354774 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | SPRY domain containing 7 | 0.659 |
MEIG1 | SYCP2 | ENSP00000367486 | ENSP00000350162 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) | 0.541 |
MEIG1 | TSSK2 | ENSP00000367486 | ENSP00000382544 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.562 |
NXF3 | MEIG1 | ENSP00000378504 | ENSP00000367486 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.665 |
NXF3 | RNF17 | ENSP00000378504 | ENSP00000255324 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.572 |
NXF3 | SYCP2 | ENSP00000378504 | ENSP00000350162 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) | 0.512 |
POLR2J | MEIG1 | ENSP00000292614 | ENSP00000367486 | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity) | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.555 |
RNF17 | MEIG1 | ENSP00000255324 | ENSP00000367486 | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.579 |
RNF17 | NXF3 | ENSP00000255324 | ENSP00000378504 | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | 0.572 |
RNF17 | SYCP2 | ENSP00000255324 | ENSP00000350162 | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) | 0.516 |
SPAG16 | MEIG1 | ENSP00000332592 | ENSP00000367486 | sperm associated antigen 16; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity) | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.991 |