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FHL5 FHL5 DNAJB13 DNAJB13 SPAG6 SPAG6 SPAG16 SPAG16 TSSK2 TSSK2 MEIG1 MEIG1 NXF3 NXF3 SPRYD7 SPRYD7 RNF17 RNF17 SYCP2 SYCP2 POLR2J POLR2J
"MEIG1" - meiosis expressed gene 1 homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MEIG1meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) (88 aa)    
Predicted Functional Partners:
SPAG16
sperm associated antigen 16; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity) (631 aa)
        score_image   score_image   0.991
SPAG6
sperm associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility (By similarity) (509 aa)
            score_image   0.898
NXF3
nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor (531 aa)
            score_image   0.665
SPRYD7
SPRY domain containing 7 (196 aa)
            score_image   0.659
RNF17
ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) (1623 aa)
            score_image   0.579
TSSK2
testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (358 aa)
            score_image   0.562
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity) (117 aa)
        score_image       0.555
SYCP2
synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) (1530 aa)
            score_image   0.541
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis (316 aa)
            score_image   0.504
FHL5
four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner (284 aa)
            score_image   0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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