node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTRT2 | CFL1 | ENSP00000367658 | ENSP00000309629 | actin-related protein T2 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.798 |
ACTRT2 | CFL2 | ENSP00000367658 | ENSP00000298159 | actin-related protein T2 | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.798 |
ACTRT2 | DSTN | ENSP00000367658 | ENSP00000246069 | actin-related protein T2 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.806 |
ACTRT2 | MYH14 | ENSP00000367658 | ENSP00000262269 | actin-related protein T2 | myosin, heavy chain 14, non-muscle | 0.808 |
ACTRT2 | MYO5A | ENSP00000367658 | ENSP00000382177 | actin-related protein T2 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.776 |
ACTRT2 | PFN1 | ENSP00000367658 | ENSP00000225655 | actin-related protein T2 | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | 0.792 |
ACTRT2 | PFN2 | ENSP00000367658 | ENSP00000239940 | actin-related protein T2 | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | 0.794 |
ACTRT2 | PFN4 | ENSP00000367658 | ENSP00000322170 | actin-related protein T2 | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.815 |
ACTRT2 | PLS1 | ENSP00000367658 | ENSP00000336831 | actin-related protein T2 | plastin 1; Actin-bundling protein in the absence of calcium | 0.775 |
ACTRT2 | PLS3 | ENSP00000367658 | ENSP00000348163 | actin-related protein T2 | plastin 3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia | 0.775 |
CFL1 | ACTRT2 | ENSP00000309629 | ENSP00000367658 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | actin-related protein T2 | 0.798 |
CFL1 | CFL2 | ENSP00000309629 | ENSP00000298159 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.868 |
CFL1 | MYH14 | ENSP00000309629 | ENSP00000262269 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | myosin, heavy chain 14, non-muscle | 0.424 |
CFL1 | MYO5A | ENSP00000309629 | ENSP00000382177 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.497 |
CFL1 | PFN1 | ENSP00000309629 | ENSP00000225655 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | 0.982 |
CFL1 | PFN2 | ENSP00000309629 | ENSP00000239940 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | 0.680 |
CFL1 | PFN4 | ENSP00000309629 | ENSP00000322170 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.611 |
CFL1 | PLS1 | ENSP00000309629 | ENSP00000336831 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | plastin 1; Actin-bundling protein in the absence of calcium | 0.662 |
CFL1 | PLS3 | ENSP00000309629 | ENSP00000348163 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | plastin 3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia | 0.658 |
CFL2 | ACTRT2 | ENSP00000298159 | ENSP00000367658 | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | actin-related protein T2 | 0.798 |