node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKB | CAMKMT | ENSP00000463999 | ENSP00000367755 | aurora kinase B | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.889 |
AURKB | HSP90AA1 | ENSP00000463999 | ENSP00000335153 | aurora kinase B | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.815 |
AURKB | HSP90AB1 | ENSP00000463999 | ENSP00000325875 | aurora kinase B | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.801 |
AURKB | PPM1B | ENSP00000463999 | ENSP00000282412 | aurora kinase B | protein phosphatase, Mg2+/Mn2+ dependent, 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro | 0.473 |
CAMKMT | AURKB | ENSP00000367755 | ENSP00000463999 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | aurora kinase B | 0.889 |
CAMKMT | CASD1 | ENSP00000367755 | ENSP00000297273 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | CAS1 domain containing 1 | 0.593 |
CAMKMT | ENSG00000269547 | ENSP00000367755 | ENSP00000472465 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | F-box only protein 17 | 0.674 |
CAMKMT | HSP90AA1 | ENSP00000367755 | ENSP00000335153 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.860 |
CAMKMT | HSP90AB1 | ENSP00000367755 | ENSP00000325875 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.855 |
CAMKMT | PPM1B | ENSP00000367755 | ENSP00000282412 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | protein phosphatase, Mg2+/Mn2+ dependent, 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro | 0.868 |
CAMKMT | PREPL | ENSP00000367755 | ENSP00000260648 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | prolyl endopeptidase-like | 0.881 |
CAMKMT | SIRT1 | ENSP00000367755 | ENSP00000212015 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...] | 0.815 |
CAMKMT | SLC3A1 | ENSP00000367755 | ENSP00000260649 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.862 |
CAMKMT | SURF2 | ENSP00000367755 | ENSP00000361032 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | surfeit 2 | 0.594 |
CASD1 | CAMKMT | ENSP00000297273 | ENSP00000367755 | CAS1 domain containing 1 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.593 |
ENSG00000269547 | CAMKMT | ENSP00000472465 | ENSP00000367755 | F-box only protein 17 | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.674 |
ENSG00000269547 | PREPL | ENSP00000472465 | ENSP00000260648 | F-box only protein 17 | prolyl endopeptidase-like | 0.712 |
HSP90AA1 | AURKB | ENSP00000335153 | ENSP00000463999 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | aurora kinase B | 0.815 |
HSP90AA1 | CAMKMT | ENSP00000335153 | ENSP00000367755 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin | 0.860 |
HSP90AA1 | HSP90AB1 | ENSP00000335153 | ENSP00000325875 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |