node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | B2M | ENSP00000284981 | ENSP00000452780 | amyloid beta (A4) precursor protein | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.916 |
APP | BACE1 | ENSP00000284981 | ENSP00000318585 | amyloid beta (A4) precursor protein | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase | 0.998 |
APP | CST3 | ENSP00000284981 | ENSP00000366124 | amyloid beta (A4) precursor protein | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | 0.943 |
APP | GSN | ENSP00000284981 | ENSP00000362924 | amyloid beta (A4) precursor protein | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.964 |
APP | IAPP | ENSP00000284981 | ENSP00000240652 | amyloid beta (A4) precursor protein | islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism | 0.923 |
APP | ITM2B | ENSP00000284981 | ENSP00000367828 | amyloid beta (A4) precursor protein | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | 0.979 |
APP | LYZ | ENSP00000284981 | ENSP00000261267 | amyloid beta (A4) precursor protein | lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents | 0.923 |
APP | SNCA | ENSP00000284981 | ENSP00000338345 | amyloid beta (A4) precursor protein | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.998 |
APP | TTR | ENSP00000284981 | ENSP00000237014 | amyloid beta (A4) precursor protein | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.972 |
APP | UBC | ENSP00000284981 | ENSP00000344818 | amyloid beta (A4) precursor protein | ubiquitin C | 0.991 |
B2M | APP | ENSP00000452780 | ENSP00000284981 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | amyloid beta (A4) precursor protein | 0.916 |
B2M | CST3 | ENSP00000452780 | ENSP00000366124 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | 0.969 |
B2M | GSN | ENSP00000452780 | ENSP00000362924 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.925 |
B2M | IAPP | ENSP00000452780 | ENSP00000240652 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism | 0.928 |
B2M | ITM2B | ENSP00000452780 | ENSP00000367828 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | 0.912 |
B2M | LYZ | ENSP00000452780 | ENSP00000261267 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents | 0.956 |
B2M | SNCA | ENSP00000452780 | ENSP00000338345 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.925 |
B2M | TTR | ENSP00000452780 | ENSP00000237014 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.948 |
B2M | UBC | ENSP00000452780 | ENSP00000344818 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | ubiquitin C | 0.790 |
BACE1 | APP | ENSP00000318585 | ENSP00000284981 | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase | amyloid beta (A4) precursor protein | 0.998 |