SEPHS1 protein (Homo sapiens) - STRING network view

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Score

SEPHS1

selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP (392 aa)

Predicted Functional Partners:

SEPSECS

0.977

SCLY

0.938

EEFSEC

0.935

TXNRD1

0.929

TXNRD2

0.921

TXNRD3

0.920

VIMP

0.760

ZBTB25

0.759

PFAS

0.739

TBPL1

0.701

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEFSEC	SEPHS1	ENSP00000254730	ENSP00000367893	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.935
EEFSEC	SEPSECS	ENSP00000254730	ENSP00000371535	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	0.807
EEFSEC	TXNRD1	ENSP00000254730	ENSP00000434516	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	thioredoxin reductase 1	0.422
EEFSEC	TXNRD3	ENSP00000254730	ENSP00000430031	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)	0.472
EEFSEC	VIMP	ENSP00000254730	ENSP00000381282	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.818
PFAS	SEPHS1	ENSP00000313490	ENSP00000367893	phosphoribosylformylglycinamidine synthase	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.739
SCLY	SEPHS1	ENSP00000254663	ENSP00000367893	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.938
SCLY	TXNRD1	ENSP00000254663	ENSP00000434516	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	thioredoxin reductase 1	0.900
SCLY	TXNRD2	ENSP00000254663	ENSP00000383365	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	thioredoxin reductase 2	0.902
SCLY	TXNRD3	ENSP00000254663	ENSP00000430031	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)	0.903
SCLY	VIMP	ENSP00000254663	ENSP00000381282	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.515
SEPHS1	EEFSEC	ENSP00000367893	ENSP00000254730	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	0.935
SEPHS1	PFAS	ENSP00000367893	ENSP00000313490	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	phosphoribosylformylglycinamidine synthase	0.739
SEPHS1	SCLY	ENSP00000367893	ENSP00000254663	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	0.938
SEPHS1	SEPSECS	ENSP00000367893	ENSP00000371535	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	0.977
SEPHS1	TBPL1	ENSP00000367893	ENSP00000237264	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	TBP-like 1; Does not bind the TATA box. Has DNA-binding ability	0.701
SEPHS1	TXNRD1	ENSP00000367893	ENSP00000434516	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	thioredoxin reductase 1	0.929
SEPHS1	TXNRD2	ENSP00000367893	ENSP00000383365	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	thioredoxin reductase 2	0.921
SEPHS1	TXNRD3	ENSP00000367893	ENSP00000430031	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)	0.920
SEPHS1	VIMP	ENSP00000367893	ENSP00000381282	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.760

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