| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GNAI1 | GPR17 | ENSP00000343027 | ENSP00000272644 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | 0.906 |
| GNAI1 | GPR18 | ENSP00000343027 | ENSP00000343428 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G protein-coupled receptor 18; Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system | 0.907 |
| GNAI1 | GPR55 | ENSP00000343027 | ENSP00000375893 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G protein-coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function | 0.900 |
| GNAI1 | LPAR1 | ENSP00000343027 | ENSP00000351755 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation | 0.937 |
| GNAI1 | NPB | ENSP00000343027 | ENSP00000332766 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity) | 0.900 |
| GNAI1 | NPY2R | ENSP00000343027 | ENSP00000332591 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid | 0.903 |
| GNAI1 | OXER1 | ENSP00000343027 | ENSP00000367930 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | 0.918 |
| GNAI1 | OXGR1 | ENSP00000343027 | ENSP00000298440 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
| GNAI1 | PTGER3 | ENSP00000343027 | ENSP00000349003 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.903 |
| GNAI1 | SUCNR1 | ENSP00000343027 | ENSP00000355156 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | succinate receptor 1; Receptor for succinate | 0.900 |
| GPR17 | GNAI1 | ENSP00000272644 | ENSP00000343027 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.906 |
| GPR17 | GPR18 | ENSP00000272644 | ENSP00000343428 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | G protein-coupled receptor 18; Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system | 0.909 |
| GPR17 | GPR55 | ENSP00000272644 | ENSP00000375893 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | G protein-coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function | 0.900 |
| GPR17 | LPAR1 | ENSP00000272644 | ENSP00000351755 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation | 0.906 |
| GPR17 | NPB | ENSP00000272644 | ENSP00000332766 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity) | 0.900 |
| GPR17 | NPY2R | ENSP00000272644 | ENSP00000332591 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid | 0.900 |
| GPR17 | OXER1 | ENSP00000272644 | ENSP00000367930 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | 0.907 |
| GPR17 | OXGR1 | ENSP00000272644 | ENSP00000298440 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.907 |
| GPR17 | PTGER3 | ENSP00000272644 | ENSP00000349003 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.905 |
| GPR17 | SUCNR1 | ENSP00000272644 | ENSP00000355156 | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | succinate receptor 1; Receptor for succinate | 0.908 |
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